Stadecker M J, Leskowitz S
J Immunol. 1976 Jun;116(6):1646-51.
Systemic treatment with a heterologous anti-T cell serum of guinea pigs immunized with EA in IFA markedly suppressed CBH reactivity to specific antigen and T cell mitogens, as judged by gross reactivity, histology, and skin histamine. The antiserum produced a marked drop in circulating lymphocytes, mainly at the expense of T cells, as indicated by the ability of surviving lymphocytes to rosette with rabbit RBC. It was postulated that the suppression of CBH reactivity is due to the depletion of T cells, which would have released a factor chemotactic for basophils. The data therefore provide further evidence that cutaneous reactions rich in basophils are primarily dependent on a population of T cells.
用在不完全弗氏佐剂中免疫的豚鼠的异种抗T细胞血清进行全身治疗，显著抑制了接触性迟发型超敏反应（CBH）对特异性抗原和T细胞有丝分裂原的反应性，这通过总体反应性、组织学和皮肤组胺来判断。抗血清使循环淋巴细胞显著减少，主要是以T细胞为代价，存活淋巴细胞与兔红细胞形成玫瑰花结的能力表明了这一点。据推测，CBH反应性的抑制是由于T细胞的耗竭，T细胞原本会释放一种对嗜碱性粒细胞有趋化作用的因子。因此，这些数据进一步证明，富含嗜碱性粒细胞的皮肤反应主要依赖于T细胞群体。
