[Effect of meproscillarin on left ventricular hemodynamics (author's transl)].

In 10 patients with angiographically proven coronary artery disease we investigated the influence of the glycoside 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) on left ventricular performance with invasive methods. After a single i.v. bolus injection a decrease in left ventricular end-diastolic pressure associated with an increase of the maximum rate of pressure rise (dp/dtmax) and left ventricular pressure (LVP) was observed. These changes were not accompanied by significant alterations of the heart rate during an observation period of 60 min.