Beckmann H, Belz G G, Quellhorst E
Arzneimittelforschung. 1978;28(3a):565-7.
It was to be investigated whether the elimination rate of 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) is influenced by the renal function after discontinuance of long-term application. A group of 9 patients with renal insufficiency of varying extent associated with heart failure received 0.75 mg of meproscillarin per day over a period of 14 days. The plasma levels of the glycoside were measured by means of the 86rubidium erythrocyte assay up to 60 h after the last dose. After discontinuance of the glycoside the mean plasma half-life was 45.8 (S.-X = 6 h), a value corresponding to the results obtained in healthy test persons (49.3 h). Thus it could be demonstrated that the rapid elimination rate (and thereby the rate of inactivation) of meproscillarin is not influenced by renal function even after discontinuance of long-term application.
研究长期应用后停药时，14-羟基-3β-[(4-O-甲基-α-L-鼠李吡喃糖基)氧基]-14β-蟾蜍-4,20,22-三烯醇内酯（美普罗西林，克利夫特）的消除率是否受肾功能影响。一组9例不同程度肾功能不全合并心力衰竭的患者，连续14天每天服用0.75毫克美普罗西林。在最后一剂后长达60小时内，通过86铷红细胞测定法测量糖苷的血浆水平。停用糖苷后，血浆平均半衰期为45.8（标准差=6小时），该值与健康测试者获得的结果（49.3小时）相符。因此可以证明，即使长期应用停药后，美普罗西林的快速消除率（以及由此的失活率）也不受肾功能影响。
