Müsch H R, Bornhausen M, Kriegel H, Greim H
Arch Toxicol. 1978 Apr 27;40(2):103-8. doi: 10.1007/BF01891964.
Methylmercury chloride (MMC) was given to pregnant rats on the 6th, 7th, 8th, and 9th day after conception in doses of 0.05 and 2.0 mg/kg/day. The female offspring of these animals were tested 90 days after birth for learning ability using operant conditioning procedures. The rats were kept at 90% of their normal body weight and trained in a lever-box to press a bar in order to obtain a food pellet. Significant differences in the acquisition speed became apparent when the ratio of bar presses to reward was increased in a classical contingency of differential reinforcement of high rates even at MMC-doses of 4 X 0.05 mg/kg. These differences were not found in the general motility level nor in motor coordination.
在受孕后的第6、7、8和9天，给怀孕大鼠每日按0.05毫克/千克和2.0毫克/千克的剂量注射氯化甲基汞（MMC）。这些动物的雌性后代在出生90天后，通过操作性条件反射程序测试学习能力。将大鼠体重维持在正常体重的90%，并在杠杆箱中训练它们按压杠杆以获取食物颗粒。当在经典的高比率差别强化条件下增加按压杠杆与奖励的比率时，即使在MMC剂量为4×0.05毫克/千克的情况下，习得速度也出现了显著差异。在一般运动水平和运动协调性方面未发现这些差异。
