Groopman John D, Egner Patricia A, Schulze Kerry J, Wu Lee S-F, Merrill Rebecca, Mehra Sucheta, Shamim Abu A, Ali Hasmot, Shaikh Saijuddin, Gernand Alison, Khatry Subarna K, LeClerq Steven C, West Keith P, Christian Parul
Department of Environmental Health Sciences, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Environmental Health Sciences, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Food Chem Toxicol. 2014 Dec;74:184-9. doi: 10.1016/j.fct.2014.09.016. Epub 2014 Oct 13.
Aflatoxin B1 is a potent carcinogen, occurring from mold growth that contaminates staple grains in hot, humid environments. In this investigation, aflatoxin B1-lysine albumin biomarkers were measured by mass spectrometry in rural South Asian women, during the first and third trimester of pregnancy, and their children at birth and at two years of age. These subjects participated in randomized community trials of antenatal micronutrient supplementation in Sarlahi District, southern Nepal and Gaibandha District in northwestern Bangladesh. Findings from the Nepal samples demonstrated exposure to aflatoxin, with 94% detectable samples ranging from 0.45 to 2939.30 pg aflatoxin B1-lysine/mg albumin during pregnancy. In the Bangladesh samples the range was 1.56 to 63.22 pg aflatoxin B1-lysine/mg albumin in the first trimester, 3.37 to 72.8 pg aflatoxin B1-lysine/mg albumin in the third trimester, 4.62 to 76.69 pg aflatoxin B1-lysine/mg albumin at birth and 3.88 to 81.44 pg aflatoxin B1-lysine/mg albumin at age two years. Aflatoxin B1-lysine adducts in cord blood samples demonstrated that the fetus had the capacity to convert aflatoxin into toxicologically active compounds and the detection in the same 2-year-old children illustrates exposure over the first 1000 days of life.
黄曲霉毒素B1是一种强效致癌物，由霉菌生长产生，在炎热潮湿的环境中会污染主食谷物。在这项调查中，采用质谱法对南亚农村地区的孕妇（孕早期和孕晚期）及其出生时和两岁时的孩子进行了黄曲霉毒素B1-赖氨酸白蛋白生物标志物检测。这些受试者参与了尼泊尔南部萨拉希区和孟加拉国西北部盖班达区的产前微量营养素补充随机社区试验。尼泊尔样本的检测结果表明存在黄曲霉毒素暴露，孕期94%的可检测样本中黄曲霉毒素B1-赖氨酸含量为0.45至2939.30 pg/毫克白蛋白。在孟加拉国样本中，孕早期黄曲霉毒素B1-赖氨酸含量范围为1.56至63.22 pg/毫克白蛋白，孕晚期为3.37至72.8 pg/毫克白蛋白，出生时为4.62至76.69 pg/毫克白蛋白，两岁时为3.88至81.44 pg/毫克白蛋白。脐带血样本中的黄曲霉毒素B1-赖氨酸加合物表明胎儿有能力将黄曲霉毒素转化为具有毒理学活性的化合物，对同一批两岁儿童的检测结果则显示在生命的前1000天存在暴露情况。
