肝内血管对亚硝酸钠的反应
Intra-hepatic vascular response to sodium nitrite.
作者信息
Geumei A, Issa I, Mahfouz M
出版信息
Br J Pharmacol. 1969 Mar;35(3):456-9. doi: 10.1111/j.1476-5381.1969.tb08286.x.
Abstract
- In the perfused liver of the dog, sodium nitrite produced vasoconstriction in the hepatic arterial bed and, particularly, in the portal venous vascular bed.2. These effects on the hepatic vasculature may account in part for the reduction of venous return and diminution in cardiac output recorded by other workers, and may therefore be a factor in the clinical efficacy of the nitrites in angina pectoris.
摘要
- 在犬的灌注肝脏中，亚硝酸钠可使肝动脉床，尤其是门静脉血管床产生血管收缩。2. 这些对肝脏血管系统的影响可能部分解释了其他研究者所记录的静脉回流减少和心输出量降低的现象，因此可能是亚硝酸盐在心绞痛临床疗效中的一个因素。
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The mechanism of cardiovascular action of nitroglycerine. An example of integrated response during the unsteady state.硝酸甘油的心血管作用机制。非稳态下综合反应的一个例子。
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