Nefelova M V, Sverdlova A N, Silaev A B
Antibiotiki. 1978 Jul;23(7):586-90.
The biosynthesis of macrotetrolides by Actinomyces chrysomalus var. carotenoides was stimulated by acetic, succinic, propionic, oxalic, malic, tartaric, citric, pyruvic, alpha-ketoglutaric and fumaric acids. Incorporation of 14C-acetate into the molecule of the antibiotic and the data on dependence of the stimulating effect upon the quantitative ratio and time of the organic acid addition were indicative of the role of acetic, succinic and propionic acids as precursors of macrotetrolides. The other organic acids increased the biosynthesis of macrotetolides when added to the culture within wide time ranges of the culture development and prolonged the period of the mycelium productive state.
类胡萝卜素黄放线菌变种合成大内酯四醇类化合物受到乙酸、琥珀酸、丙酸、草酸、苹果酸、酒石酸、柠檬酸、丙酮酸、α-酮戊二酸和富马酸的刺激。14C-乙酸掺入抗生素分子以及刺激作用对有机酸添加量的定量比例和时间的依赖性数据表明，乙酸、琥珀酸和丙酸作为大内酯四醇类化合物前体的作用。当在培养物生长的较宽时间范围内添加到培养物中时，其他有机酸增加了大内酯四醇类化合物的生物合成，并延长了菌丝体生产状态的时期。
