Fagan D G, Forrest J B, Enhörning G, Lamprey M, Guy J
Histopathology. 1977 May;1(3):209-23. doi: 10.1111/j.1365-2559.1977.tb01660.x.
The death of an adolescent after deliberate inhalation of the domestic fluorocarbon--lipid spray, PAM, triggered an investigation of the effects of this product on mammalian lung. Some of its constituents are known to destroy the lung-surfactant system, but death from its inhalation by earlier victims was usually attributed to the fluorocarbon's cardiac arrhythmogenic properties. In the present study, we applied methods and experimental models not previously used to study the effects of this aerosol material on the lung surfactant. We found morphological and functional acute disintegration of normal alveolar surfactant, leading to extensive alveolar collapse, with sustained and elevated surface tensions in vitro. This could result in fatal hypoxaemia at inspired concentrations of fluorocarbons insufficient to cause cardiac arrhythmias, and may explain at least partly the large number of deaths associated with inhalation of such product.
一名青少年因故意吸入家用含氟碳化合物的脂质喷雾PAM后死亡，引发了对该产品对哺乳动物肺部影响的调查。已知其某些成分会破坏肺表面活性物质系统，但早期受害者因吸入该产品而死亡通常归因于氟碳化合物的致心律失常特性。在本研究中，我们应用了以前未用于研究这种气雾剂材料对肺表面活性剂影响的方法和实验模型。我们发现正常肺泡表面活性剂出现形态和功能上的急性崩解，导致广泛的肺泡塌陷，体外表面张力持续升高。这可能在吸入的氟碳化合物浓度不足以引起心律失常时导致致命的低氧血症，并且至少可以部分解释与吸入此类产品相关的大量死亡。
