Johansen K, Hansen J M, Skovsted L
Acta Endocrinol (Copenh). 1978 Aug;88(4):691-7. doi: 10.1530/acta.0.0880691.
Serum TSH values and the free concentration of T4 and T3 in serum expressed as the free T4- and T3-indices showed a curvilinear relationship in 24 patients with manifest hypothyroidism mainly due to extremely elevated serum TSH levels associated with very low thyroid hormone levels. The same degree of negative correlation was found between the log serum TSH concentration and serum free T4-index (r = -0.51, P less than 0.05) and between log serum TSH concentration and serum free T3-index (r = -0.47, P less than 0.05). The correlation coefficients dropped to non-significant levels when the interdependence between the free T3- and T4-indices was taken into account and eliminated by partial correlation analysis. The degree of negative correlation between serum TSH and the thyroid hormones was also of the same order of magnitude in 5 hypothyroid patients studied prosepctively during treatment with L-thyroxine (TSH vs. T4: mean r = -0.71; TSH vs T3: mean r = -0.79).
在24例明显甲状腺功能减退患者中，血清促甲状腺激素（TSH）值以及以游离T4和T3指数表示的血清中T4和T3的游离浓度呈现出曲线关系，这主要是由于血清TSH水平极高且甲状腺激素水平极低所致。在对数血清TSH浓度与血清游离T4指数之间（r = -0.51，P < 0.05）以及对数血清TSH浓度与血清游离T3指数之间（r = -0.47，P < 0.05）发现了相同程度的负相关。当通过偏相关分析考虑并消除游离T3和T4指数之间的相互依赖性时，相关系数降至无显著意义的水平。在5例接受左甲状腺素治疗的前瞻性研究的甲状腺功能减退患者中，血清TSH与甲状腺激素之间的负相关程度也处于相同的数量级（TSH与T4：平均r = -0.71；TSH与T3：平均r = -0.79）。
