Schimpff R M, Lebrec D, Dannadieu M, Repellin A M
Acta Endocrinol (Copenh). 1978 Aug;88(4):729-36. doi: 10.1530/acta.0.0880729.
Serum somatomedin (SM) activity, measured as sulphation factor on chick embryo cartilage, and growth hormone (GH) levels were measured in peripheral, hepatic and renal veins of 23 patients with a alcoholic cirrhosis. SM activity (mean +/- SEM) was 0.65 +/- 0.05 U/ml in peripheral vein, 0.59 +/- 0.04 U/ml in hepatic vein, and 0.74 +/- 0.07 U/ml in renal vein. Mean GH levels were respectively 2.8, 2.5 and 3.1 ng/ml. Compared to peripheral vein, SM increase in renal vein was 19% (P less than 0.05). Serum SM activity was significantly lower in 13 patients with alcoholic hepatitis associated with cirrhosis than in other 10 patients (P less than 0.02 in hepatic blood and P less than 0.05 in peripheral blood). The decrease of SM activity seems related to cytolysis and hepato-cellular insufficiency. At last, in patients with alcoholic hepatitis, SM activity was lower in the hepatic vein than in the peripheral vein (P less than 0.05). The cause of this difference remains under discussion, no SM inhibitors being found in the serum samples used in this study.
对23例酒精性肝硬化患者的外周静脉、肝静脉和肾静脉血进行检测，以鸡胚软骨硫酸化因子为指标测定血清生长调节素（SM）活性，并检测生长激素（GH）水平。外周静脉血中SM活性（均值±标准误）为0.65±0.05 U/ml，肝静脉血中为0.59±0.04 U/ml，肾静脉血中为0.74±0.07 U/ml。GH平均水平分别为2.8、2.5和3.1 ng/ml。与外周静脉相比，肾静脉血中SM升高了19%（P<0.05）。13例合并酒精性肝炎的肝硬化患者血清SM活性显著低于另外10例患者（肝血中P<0.02，外周血中P<0.05）。SM活性降低似乎与细胞溶解和肝细胞功能不全有关。最后，酒精性肝炎患者肝静脉血中SM活性低于外周静脉血（P<0.05）。这种差异的原因仍在探讨中，本研究使用的血清样本中未发现SM抑制剂。
