Schimpff R M, Donnadieu M, Duval M
Acta Endocrinol (Copenh). 1980 Jan;93(1):67-72. doi: 10.1530/acta.0.0930067.
Serum somatomedin (SM) activity measured as sulphation factor on chick embryo cartilage was determined in peripheral (PV), hepatic (HV) and renal (RV) veins or 36 mongrel dogs. Mean SM activity +/- SEM was 0.53 +/- 0.03 U/ml in peripheral and hepatic veins, and 0.61 +/- 0.04 U/ml in renal vein (P less than 0.005). When the gradient of SM activity in hepatic or renal vein to that in peripheral vein, [HV]-[PV] or [HV]-[PV], was plotted versus SM activity in peripheral blood [PV], a negative correlation was found in the case of hepatic but not of renal blood. These data indicate that the kidney may be a production site of SM activity, whereas the liver is differently implicated in the overall regulation of SM activity.
在36只杂种狗的外周静脉（PV）、肝静脉（HV）和肾静脉（RV）中测定了以鸡胚软骨硫酸化因子衡量的血清生长调节素（SM）活性。外周静脉和肝静脉中的平均SM活性±标准误为0.53±0.03 U/ml，肾静脉中的为0.61±0.04 U/ml（P<0.005）。当将肝静脉或肾静脉中SM活性与外周静脉中SM活性的梯度，即[HV]-[PV]或[RV]-[PV]，与外周血中SM活性[PV]作图时，发现肝血情况呈负相关，而肾血情况并非如此。这些数据表明，肾脏可能是SM活性的产生部位，而肝脏在SM活性的整体调节中所起作用不同。
