Schimpff R M, Donnadieu M, Duval M
Acta Endocrinol (Copenh). 1980 Feb;93(2):155-61. doi: 10.1530/acta.0.0930155.
The aim of this work was to study the early effects of an intravenous growth hormone (GH) injection on serum somatomedin (SM) activity in samples from peripheral (PV), hepatic (HV) and renal (RV) veins in dogs: 5 dogs were given one bovine growth hormone (bGH) injection, 1 dog was given 5 different doses of human growth hormone (hGH) and 6 control dogs were given saline. In bGH-treated dogs, a significant increase of SM activity occurred in the three vessels without difference between vessels. An early paradoxical decrease of serum somatomedin activity appeared in the dogs given more than 1.15 IU/kg. In the dog given hGH, the response of SM activity was significantly related to the hGH dose in the PV and not in the other vessels. These data seem to indicate that other sites than the liver and the kidney are involved in the production of GH-induced serum somatomedin activity. Following GH injection as well as in basal status, the liver may be implicated in the regulation of serum somatomedin activity.
这项工作的目的是研究静脉注射生长激素（GH）对犬外周静脉（PV）、肝静脉（HV）和肾静脉（RV）样本中血清生长调节素（SM）活性的早期影响：给5只犬注射一次牛生长激素（bGH），给1只犬注射5种不同剂量的人生长激素（hGH），给6只对照犬注射生理盐水。在接受bGH治疗的犬中，三根血管中的SM活性均显著增加，各血管之间无差异。在接受超过1.15 IU/kg hGH的犬中，血清生长调节素活性早期出现反常下降。在接受hGH治疗的犬中，PV中SM活性的反应与hGH剂量显著相关，而在其他血管中则不然。这些数据似乎表明，除肝脏和肾脏外，其他部位也参与了GH诱导的血清生长调节素活性的产生。在注射GH后以及基础状态下，肝脏可能参与血清生长调节素活性的调节。
