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宽带噪声暴露后大鼠螺旋神经节细胞的超微结构形态计量学变化(作者译)

[Ultrastructural morphometric changes in spiral ganglion cells of the rat after broad band noise (author's transl)].

作者信息

Merck W, Riede U N, Beck C, Hoff J, Leupe M

出版信息

Arch Otorhinolaryngol. 1978 Jun 27;220(3):193-9. doi: 10.1007/BF00457487.

Abstract

The comparison of ultrastructural and ultrastructural-morphometric findings in spiral ganglion cells subsequent to broad noise with 105 dB SPL over a period of 40 min demonstrates that there are morphometric changes of the cytoarchitecture of granular ganglion cells even without evident ultrastructural changes. Morphometric analyses shows a significant extension of the volume proportion of mitochondria per unit volume cytoplasm. The volume and the surface of the rough endoplasmic reticulum, the volume of the free ribosomes and the average single volume of the nucleoli increase per granular ganglion cell. The physiologic significance of these changes is discussed. The results show that changes of the cytoarchitecture of granular spiral ganglion cells are earlier detected by morphometry than by ultrastructural description.

摘要

对在40分钟内暴露于105 dB SPL的宽频噪声后螺旋神经节细胞的超微结构和超微结构形态学测量结果进行比较,结果表明,即使没有明显的超微结构变化,颗粒神经节细胞的细胞结构也存在形态学测量变化。形态学分析显示,每单位体积细胞质中线粒体的体积比例显著增加。每个颗粒神经节细胞的粗面内质网的体积和表面积、游离核糖体的体积以及核仁的平均单一体积均增加。文中讨论了这些变化的生理意义。结果表明,通过形态学测量比通过超微结构描述能更早地检测到颗粒螺旋神经节细胞的细胞结构变化。

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