Enhorning G, Chamberlain D, Contreras C, Burgoyne R, Robertson B
Biol Neonate. 1979;35(1-2):43-51. doi: 10.1159/000241152.
Rabbit does, pregnant on the 28th day, were infused with isoxsuprine 2.5 mg/kg body weight/h in 50 ml 5% glucose, or with glucose only. The isoxsuprine caused maternal heart rate to increase and blood pressure, mean and diastolic, to decrease. The volume of fetal pulmonary fluid (FPF) and the wet lung weight/body weight ratio were significantly lowered by isoxsuprine. Lecithin/sphingomyelin ratio of FPF in isoxsuprine-infused animals was higher, compared with controls, not infused. Minimal surface tension of FPF, evaluated with pulsating bubble, was significantly lower in treated fetuses. Histologic examination of the fetal lungs after fixation with potassium dichromate and mercuric chloride showed that in isoxsuprine-treated litters FPF contained more granular and sudanophilic material. The results offer further evidence that isoxsuprine causes dehydration of fetal lungs and a release of pulmonary surfactant.
在妊娠第28天的兔身上，以每千克体重每小时2.5毫克的异舒普林溶于50毫升5%葡萄糖溶液中进行输注，或仅输注葡萄糖溶液。异舒普林使母体心率增加，平均血压和舒张压降低。异舒普林显著降低了胎儿肺液（FPF）的量以及湿肺重量与体重的比值。与未输注异舒普林的对照组相比，输注异舒普林动物的胎儿肺液中卵磷脂/鞘磷脂比值更高。用脉动气泡法评估，处理过的胎儿的胎儿肺液最小表面张力显著更低。用重铬酸钾和氯化汞固定后对胎儿肺部进行组织学检查表明，在接受异舒普林处理的胎仔中，胎儿肺液含有更多的颗粒状和嗜苏丹物质。这些结果进一步证明异舒普林会导致胎儿肺部脱水并释放肺表面活性物质。
