母体异舒普林对胎兔肺生化成熟的影响。

Effect of maternal isoxsuprine on fetal rabbit lung biochemical maturation.

作者信息

Hayden W, Olson E B, Zachman R D

出版信息

Am J Obstet Gynecol. 1977 Nov 15;129(6):691-4. doi: 10.1016/0002-9378(77)90654-8.

PMID:200142

Abstract

Isoxsuprine was given intramuscularly for 24 hours to pregnant rabbits at 26 to 27 days' gestation. There was no effect on fetal weight within one day of the last injection. Fetuses of isoxsuprine-treated mothers had higher lung lecithin (6.67 micron per gram +/- 2.81) and higher tracheal wash lecithin/sphingomyelin (L/S) ratios (5.85 +/- 4.5) than did untreated fetuses--lung lecithin (5.35 micron per gram 1.23) and tracheal wash L/S (4.08 +/- 2.3). In contrast, phosphorylcholine glyceride transferase activity of the fetal lung was less in isoxsuprine-treated fetal lung tissue.

摘要

在妊娠26至27天的孕兔中，肌肉注射异克舒令24小时。在最后一次注射后一天内，对胎儿体重无影响。与未治疗的胎儿相比，接受异克舒令治疗的母亲所生胎儿的肺卵磷脂含量更高（6.67微克/克±2.81），气管冲洗液中的卵磷脂/鞘磷脂（L/S）比值更高（5.85±4.5），未治疗胎儿的肺卵磷脂含量为5.35微克/克±1.23，气管冲洗液L/S为4.08±2.3。相比之下，异克舒令治疗的胎儿肺组织中，胎儿肺的磷酸胆碱甘油酯转移酶活性较低。