Schmidt W A, Schaap R N, Mortensen J D
Arch Pathol Lab Med. 1979 Sep;103(10):516-21.
Little is known regarding the early pathogenesis of intubation-induced laryngotracheal damage or the effects of presently used soft-cuff endotracheal tubes. We have examined the pathological changes of short-term intubation (four hours) in six mongrel dogs. Interaction of the endotracheal tube with the mucosa produced a variety of lesions ranging from superficial abrasions to ulcerations with the most severe lesions in the respiratory epithelium. Changes are present at the free surfaces of ciliated cells that include flattening, fusion, and erosion of cilia of sufficient extent to compromise ciliary function. The ischemic and mechanical modes of injury are compared; the latter is considered causal with modern soft-cuff tubes. These studies reveal tube-induced mucosal damage of an extent and nature not previously appreciated.
关于插管引起的喉气管损伤的早期发病机制或目前使用的软套囊气管导管的影响，人们了解甚少。我们检查了六只杂种狗短期插管（四小时）后的病理变化。气管导管与黏膜的相互作用产生了从表面擦伤到溃疡的各种病变，其中呼吸道上皮的病变最为严重。纤毛细胞的游离表面出现了变化，包括纤毛扁平化、融合和侵蚀，其程度足以损害纤毛功能。比较了缺血性和机械性损伤模式；后者被认为是现代软套囊导管造成损伤的原因。这些研究揭示了导管引起的黏膜损伤，其程度和性质是以前未认识到的。
