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异烟肼和利血平对缩窄的肾上腺素能神经中颗粒小泡和去甲肾上腺素积累的影响。

The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves.

作者信息

Banks P, Kapeller K, Mayor D

出版信息

Br J Pharmacol. 1969 Sep;37(1):10-8. doi: 10.1111/j.1476-5381.1969.tb09516.x.

DOI:10.1111/j.1476-5381.1969.tb09516.x
PMID:5824926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703785/
Abstract
  1. The accumulation of granular vesicles proximal to a constriction applied to hypogastric nerves has been investigated with the electron microscope in cats treated with reserpine and/or iproniazid.2. The ultrastructural changes have been correlated with the accumulation of noradrenaline at the same site in similarly treated animals.3. The findings give further support to the view that granular vesicles constitute a major storage site for intraneuronal noradrenaline.
摘要
  1. 运用电子显微镜，对用利血平和/或异烟酰异丙肼处理过的猫，研究了在施加于腹下神经的缩窄处近端颗粒小泡的积聚情况。2. 超微结构变化已与在同样处理过的动物中同一部位去甲肾上腺素的积聚相关联。3. 这些发现进一步支持了颗粒小泡构成神经元内去甲肾上腺素主要储存部位这一观点。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76a9/1703785/81e1bb97569b/brjpharm00567-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76a9/1703785/852b60b9769e/brjpharm00567-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76a9/1703785/81e1bb97569b/brjpharm00567-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76a9/1703785/852b60b9769e/brjpharm00567-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76a9/1703785/81e1bb97569b/brjpharm00567-0022-a.jpg

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1
The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves.异烟肼和利血平对缩窄的肾上腺素能神经中颗粒小泡和去甲肾上腺素积累的影响。
Br J Pharmacol. 1969 Sep;37(1):10-8. doi: 10.1111/j.1476-5381.1969.tb09516.x.
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[Changes in the large granular vesicles in sympathetic nerve endings under the influence of several pharmacologic agents].[几种药理剂作用下交感神经末梢中大颗粒囊泡的变化]
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引用本文的文献

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On the axonal migration of catecholamines in constricted sciatic nerve of the rat. A radioautographic study.大鼠坐骨神经缩窄处儿茶酚胺的轴突迁移：放射自显影研究
Z Zellforsch Mikrosk Anat. 1973 Apr 17;138(3):345-70. doi: 10.1007/BF00307098.
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Further evidence for the involvement of microtubules in the intra-axonal movement of noradrenaline storage granules.关于微管参与去甲肾上腺素储存颗粒轴突内移动的进一步证据。
J Physiol. 1971 Dec;219(3):755-61. doi: 10.1113/jphysiol.1971.sp009688.
3
The effect of tetrabenazine on the accumulation of noradrenaline in constricted postganglionic sympathetic nerves in vitro.

本文引用的文献

1
AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES.一种改进的血浆和组织中微量肾上腺素和去甲肾上腺素荧光测定方法。
Acta Physiol Scand. 1963 Nov;59:242-54. doi: 10.1111/j.1748-1716.1963.tb02739.x.
2
Fluorescence microscopy and electron microscopy of adrenergic nerves after constriction at two points.两点缩窄后肾上腺素能神经的荧光显微镜检查和电子显微镜检查
J R Microsc Soc. 1967;87(2):277-94.
3
The effect of reserpine and tetrabenazine on the accumulation of noradrenaline in the rat sciatic nerve after ligation.
丁苯那嗪对体外收缩的节后交感神经中去甲肾上腺素蓄积的影响。
Cell Tissue Res. 1975 Jul 23;160(4):495-504. doi: 10.1007/BF00225766.
4
Two populations or granular vesicles in constricted post-ganglionic sympathetic nerves.节后交感神经缩窄处的两种群体或颗粒小泡。
J Physiol. 1975 Mar;245(3):727-35. doi: 10.1113/jphysiol.1975.sp010871.
利血平和丁苯那嗪对结扎后大鼠坐骨神经中去甲肾上腺素蓄积的影响。
Acta Physiol Scand. 1967 Mar;69(3):167-79. doi: 10.1111/j.1748-1716.1967.tb03508.x.
4
The effect of reserpine on the intraneuronal vesicles of the rat vas deferens.利血平对大鼠输精管神经内小泡的作用。
Experientia. 1966 Jan 15;22(1):56. doi: 10.1007/BF01897771.
5
[Ultrastructural modifications induced by several drugs on adrenergic nerve endings and on the adrenal medulla].[几种药物对肾上腺素能神经末梢和肾上腺髓质的超微结构改变]
Experientia. 1965 Mar 15;21(3):171-6. doi: 10.1007/BF02142003.
6
Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression.压迫后外周肾上腺素能神经近端和远端去甲肾上腺素蓄积的观察
J Anat. 1965 Oct;99(Pt 4):677-89.
7
The neurotubular system of the axon and the origin of granulated and non-granulated vesicles in regenerating nerves.轴突的神经微管系统以及再生神经中颗粒状和非颗粒状囊泡的起源。
Z Zellforsch Mikrosk Anat. 1968;87(3):330-44. doi: 10.1007/BF00333684.
8
Various types of amine-storing vesicles in peripheral adrenergic nerve terminals.外周肾上腺素能神经末梢中各种类型的胺储存囊泡。
Experientia. 1968 May 15;24(5):484-6. doi: 10.1007/BF02144407.
9
An electron microscopic study of the early changes distal to a constriction in sympathetic nerves.交感神经缩窄远端早期变化的电子显微镜研究。
Proc R Soc Lond B Biol Sci. 1969 Mar 11;172(1026):53-63. doi: 10.1098/rspb.1969.0011.
10
An electron microscopic study of the early changes proximal to a constriction in sympathetic nerves.
Proc R Soc Lond B Biol Sci. 1969 Mar 11;172(1026):39-51. doi: 10.1098/rspb.1969.0010.