异烟肼和利血平对缩窄的肾上腺素能神经中颗粒小泡和去甲肾上腺素积累的影响。
The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves.
作者信息
Banks P, Kapeller K, Mayor D
出版信息
Br J Pharmacol. 1969 Sep;37(1):10-8. doi: 10.1111/j.1476-5381.1969.tb09516.x.
Abstract
- The accumulation of granular vesicles proximal to a constriction applied to hypogastric nerves has been investigated with the electron microscope in cats treated with reserpine and/or iproniazid.2. The ultrastructural changes have been correlated with the accumulation of noradrenaline at the same site in similarly treated animals.3. The findings give further support to the view that granular vesicles constitute a major storage site for intraneuronal noradrenaline.
摘要
- 运用电子显微镜，对用利血平和/或异烟酰异丙肼处理过的猫，研究了在施加于腹下神经的缩窄处近端颗粒小泡的积聚情况。2. 超微结构变化已与在同样处理过的动物中同一部位去甲肾上腺素的积聚相关联。3. 这些发现进一步支持了颗粒小泡构成神经元内去甲肾上腺素主要储存部位这一观点。
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