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一项关于迟发型超敏反应向应答和不应答豚鼠被动转移至二硝基苯基-聚-L-赖氨酸和二硝基苯基-球蛋白的研究。

A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs.

作者信息

Green I, Paul W E, Benacerraf B

出版信息

J Exp Med. 1967 Nov 1;126(5):959-67. doi: 10.1084/jem.126.5.959.

DOI:10.1084/jem.126.5.959
PMID:6062006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138395/
Abstract

A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and to DNP-GL was performed in Hartley guinea pigs. Delayed hypersensitivity to DNP-PLL and DNP-GL could be transferred successfully only by means of sensitized cells from genetic responder guinea pigs and in most cases, only into those guinea pigs genetically capable of responding to PLL. The inability to transfer delayed hypersensitivity to DNP-PLL or DNP-GL to genetic nonresponder guinea pigs is not the result of the early destruction of the transferred cells by an incompatible host, since it was shown that delayed hypersensitivity to ovalbumin could be successfully transferred from guinea pigs with the PLL gene into genetic nonresponder animals. The requirement of active participation of specific and genetically controlled host mechanisms in the successful passive transfer of delayed sensitivity to DNP-PLL and DNP-GL has been demonstrated.

摘要

在哈特利豚鼠身上进行了一项关于对二硝基苯 - 聚 -L-赖氨酸（DNP-poly-L-lysine）和二硝基苯 - 球蛋白（DNP-GL）迟发型超敏反应被动转移的研究。对DNP-PLL和DNP-GL的迟发型超敏反应仅能通过来自遗传性反应性豚鼠的致敏细胞成功转移，并且在大多数情况下，只能转移到那些在遗传上能够对PLL产生反应的豚鼠体内。无法将对DNP-PLL或DNP-GL的迟发型超敏反应转移到遗传性无反应性豚鼠身上，并非是由于不相容的宿主对转移细胞的早期破坏所致，因为已表明对卵清蛋白的迟发型超敏反应能够从具有PLL基因的豚鼠成功转移到遗传性无反应性动物体内。已经证明，在对DNP-PLL和DNP-GL迟发型超敏反应的成功被动转移中，特定的和受遗传控制的宿主机制需要积极参与。

相似文献

1
A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs.一项关于迟发型超敏反应向应答和不应答豚鼠被动转移至二硝基苯基-聚-L-赖氨酸和二硝基苯基-球蛋白的研究。
J Exp Med. 1967 Nov 1;126(5):959-67. doi: 10.1084/jem.126.5.959.
2
Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs.通过来自有反应性豚鼠的骨髓或淋巴结及脾细胞，将对多聚-L-赖氨酸以及L-谷氨酸与L-赖氨酸共聚物的半抗原共轭物的反应性转移给经致死剂量照射的无反应性豚鼠。
J Exp Med. 1969 Nov 1;130(5):1107-22. doi: 10.1084/jem.130.5.1107.
3
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
4
Hapten carrier relationships in the DNP-PLL foreign albumin complex system: induction of tolerance and stimulation of cells in vitro.二硝基苯-多聚赖氨酸-异种白蛋白复合系统中的半抗原-载体关系：耐受性的诱导及体外细胞刺激
J Exp Med. 1968 Jan 1;127(1):43-53. doi: 10.1084/jem.127.1.43.
5
Specific immune response genes of the guinea pig. II. Relationship between the poly-L-lysine gene and the genes controlling immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine in random-bred Hartley guinea pigs.豚鼠的特异性免疫反应基因。II. 随机繁殖的哈特利豚鼠中聚-L-赖氨酸基因与控制对L-谷氨酸和L-丙氨酸以及L-谷氨酸和L-酪氨酸共聚物免疫反应性的基因之间的关系。
J Exp Med. 1971 Aug 1;134(2):471-81. doi: 10.1084/jem.134.2.471.
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The effect of the amount of mycobacterial adjuvants on the immune response of strain 2, strain 13 and Hartley strain guinea pigs to DNP-PLL and DNP-GL.分枝杆菌佐剂用量对2号菌株、13号菌株和哈特利品系豚鼠针对二硝基苯-多聚赖氨酸（DNP-PLL）和二硝基苯-球蛋白（DNP-GL）的免疫反应的影响。
J Immunol. 1969 Sep;103(3):403-12.
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Cellular localization of anti-DNP-PLL and anticonveyor albumin antibodies in genetic nonresponder guinea pigs immunized with DNP-PLL albumin complexes.用二硝基苯-多聚赖氨酸-白蛋白复合物免疫的遗传性无反应豚鼠中抗二硝基苯-多聚赖氨酸和抗载体白蛋白抗体的细胞定位。
J Exp Med. 1967 Mar 1;125(3):527-36. doi: 10.1084/jem.125.3.527.
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Genetic control of cutaneous basophil hypersensitivity.皮肤嗜碱性粒细胞超敏反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):206-10. doi: 10.1084/jem.143.1.206.
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Responder strain-specific enhancement of endothelial and mononuclear cell Ia in delayed hypersensitivity reactions in (strain 2 X strain 13)F1 guinea pigs.（2系×13系）F1代豚鼠迟发型超敏反应中反应株特异性增强内皮细胞和单核细胞Ia抗原表达
J Immunol. 1986 Oct 1;137(7):2132-8.
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Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.抗半抗原抗体反应中的载体功能。IV. 诱导半抗原特异性耐受或通过“非免疫原性”半抗原-多肽偶联物刺激抗半抗原回忆反应的实验条件。
J Exp Med. 1971 Jul 1;134(1):201-23. doi: 10.1084/jem.134.1.201.

引用本文的文献

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The guinea pig as a model of infectious diseases.豚鼠作为传染病模型。
Comp Med. 2008 Aug;58(4):324-40.
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H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.与H-2相关的基因，其可改变C57BL/10小鼠对鼠麻风杆菌皮下感染的抵抗力。
Infect Immun. 1984 Dec;46(3):635-8. doi: 10.1128/iai.46.3.635-638.1984.
3
The nature of the antigenic determinant in a genetic control of the antibody response.抗体应答遗传控制中抗原决定簇的性质。
J Exp Med. 1969 Sep 1;130(3):493-504. doi: 10.1084/jem.130.3.493.
4
A cellular deficit in the reconstitutive capacity of immune populations of lymphoid cells demonstrable in studies of delayed hypersensitivity in mice. Evidence for thymus-bone marrow cell synergism.在小鼠迟发型超敏反应研究中可证实的淋巴细胞免疫群体重建能力的细胞缺陷。胸腺 - 骨髓细胞协同作用的证据。
J Exp Med. 1971 May 1;133(5):1061-73. doi: 10.1084/jem.133.5.1061.
5
Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs.通过来自有反应性豚鼠的骨髓或淋巴结及脾细胞，将对多聚-L-赖氨酸以及L-谷氨酸与L-赖氨酸共聚物的半抗原共轭物的反应性转移给经致死剂量照射的无反应性豚鼠。
J Exp Med. 1969 Nov 1;130(5):1107-22. doi: 10.1084/jem.130.5.1107.
6
Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin.介导移植物抗宿主反应的淋巴细胞间的协同作用。II. 不同解剖学来源的Balb-c淋巴细胞产生的移植物抗宿主反应中的协同作用。
J Exp Med. 1970 Feb;131(2):235-46. doi: 10.1084/jem.131.2.235.
7
Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
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H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.H-2基因复合体限制小鼠迟发型超敏反应的转移。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5095-8. doi: 10.1073/pnas.72.12.5095.

本文引用的文献

1
A theory of delayed hypersensitivity.一种迟发型超敏反应理论。
Science. 1962 Jun 22;136(3521):1032-9. doi: 10.1126/science.136.3521.1032.
2
IMMUNOGENICITY OF ANTIGEN-CONTAINING RIBONUCLEIC ACID PREPARATIONS FROM MACROPHAGES.来自巨噬细胞的含抗原核糖核酸制剂的免疫原性
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GENETIC CONTROL IN GUINEA PIGS OF IMMUNE RESPONSE TO CONJUGATES OF HAPTENS AND POLY-L-LYSINE.豚鼠对半抗原与聚-L-赖氨酸偶联物免疫反应的遗传控制
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STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
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5
Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性
J Exp Med. 1963 Jan 1;117(1):55-69. doi: 10.1084/jem.117.1.55.
6
Antibody formation initiated in vitro. II. Antibody synthesis in x-irradiated recipients of diffusion chambers containing nucleic acid derived from macrophages incubated with antigen.体外引发的抗体形成。II. 在接受含有与抗原孵育的巨噬细胞衍生核酸的扩散室的X射线照射受体中的抗体合成。
J Exp Med. 1963 Apr 1;117(4):595-602. doi: 10.1084/jem.117.4.595.
7
Immunochemical studies on the antigenic determinants required to elicit delayed and immediate hypersensitivity reactions.关于引发迟发型和速发型超敏反应所需抗原决定簇的免疫化学研究。
J Exp Med. 1966 Jun 1;123(6):1083-95. doi: 10.1084/jem.123.6.1083.
8
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
9
The induction of contact hypersensitivity to dinitrochlorobenzene (DNCB) in guinea-pigs by dinitrophenyl-amino acids.二硝基苯基氨基酸对豚鼠诱导产生对二硝基氯苯（DNCB）的接触性超敏反应
Int Arch Allergy Appl Immunol. 1966;29(2):174-84. doi: 10.1159/000229698.
10
Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity.胸导管细胞的免疫能力。I. 迟发型超敏反应。
J Exp Med. 1966 Feb 1;123(2):267-81. doi: 10.1084/jem.123.2.267.