一项关于迟发型超敏反应向应答和不应答豚鼠被动转移至二硝基苯基-聚-L-赖氨酸和二硝基苯基-球蛋白的研究。
A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs.
作者信息
Green I, Paul W E, Benacerraf B
出版信息
J Exp Med. 1967 Nov 1;126(5):959-67. doi: 10.1084/jem.126.5.959.
Abstract
A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and to DNP-GL was performed in Hartley guinea pigs. Delayed hypersensitivity to DNP-PLL and DNP-GL could be transferred successfully only by means of sensitized cells from genetic responder guinea pigs and in most cases, only into those guinea pigs genetically capable of responding to PLL. The inability to transfer delayed hypersensitivity to DNP-PLL or DNP-GL to genetic nonresponder guinea pigs is not the result of the early destruction of the transferred cells by an incompatible host, since it was shown that delayed hypersensitivity to ovalbumin could be successfully transferred from guinea pigs with the PLL gene into genetic nonresponder animals. The requirement of active participation of specific and genetically controlled host mechanisms in the successful passive transfer of delayed sensitivity to DNP-PLL and DNP-GL has been demonstrated.
摘要
在哈特利豚鼠身上进行了一项关于对二硝基苯 - 聚 -L-赖氨酸（DNP-poly-L-lysine）和二硝基苯 - 球蛋白（DNP-GL）迟发型超敏反应被动转移的研究。对DNP-PLL和DNP-GL的迟发型超敏反应仅能通过来自遗传性反应性豚鼠的致敏细胞成功转移，并且在大多数情况下，只能转移到那些在遗传上能够对PLL产生反应的豚鼠体内。无法将对DNP-PLL或DNP-GL的迟发型超敏反应转移到遗传性无反应性豚鼠身上，并非是由于不相容的宿主对转移细胞的早期破坏所致，因为已表明对卵清蛋白的迟发型超敏反应能够从具有PLL基因的豚鼠成功转移到遗传性无反应性动物体内。已经证明，在对DNP-PLL和DNP-GL迟发型超敏反应的成功被动转移中，特定的和受遗传控制的宿主机制需要积极参与。
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A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs.一项关于迟发型超敏反应向应答和不应答豚鼠被动转移至二硝基苯基-聚-L-赖氨酸和二硝基苯基-球蛋白的研究。
J Exp Med. 1967 Nov 1;126(5):959-67. doi: 10.1084/jem.126.5.959.
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The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
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Genetic control of cutaneous basophil hypersensitivity.皮肤嗜碱性粒细胞超敏反应的遗传控制。
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A cellular deficit in the reconstitutive capacity of immune populations of lymphoid cells demonstrable in studies of delayed hypersensitivity in mice. Evidence for thymus-bone marrow cell synergism.在小鼠迟发型超敏反应研究中可证实的淋巴细胞免疫群体重建能力的细胞缺陷。胸腺 - 骨髓细胞协同作用的证据。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
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本文引用的文献
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A theory of delayed hypersensitivity.一种迟发型超敏反应理论。
Science. 1962 Jun 22;136(3521):1032-9. doi: 10.1126/science.136.3521.1032.
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IMMUNOGENICITY OF ANTIGEN-CONTAINING RIBONUCLEIC ACID PREPARATIONS FROM MACROPHAGES.来自巨噬细胞的含抗原核糖核酸制剂的免疫原性
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GENETIC CONTROL IN GUINEA PIGS OF IMMUNE RESPONSE TO CONJUGATES OF HAPTENS AND POLY-L-LYSINE.豚鼠对半抗原与聚-L-赖氨酸偶联物免疫反应的遗传控制
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STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
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Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性
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Antibody formation initiated in vitro. II. Antibody synthesis in x-irradiated recipients of diffusion chambers containing nucleic acid derived from macrophages incubated with antigen.体外引发的抗体形成。II. 在接受含有与抗原孵育的巨噬细胞衍生核酸的扩散室的X射线照射受体中的抗体合成。
J Exp Med. 1963 Apr 1;117(4):595-602. doi: 10.1084/jem.117.4.595.
7
Immunochemical studies on the antigenic determinants required to elicit delayed and immediate hypersensitivity reactions.关于引发迟发型和速发型超敏反应所需抗原决定簇的免疫化学研究。
J Exp Med. 1966 Jun 1;123(6):1083-95. doi: 10.1084/jem.123.6.1083.
8
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
9
The induction of contact hypersensitivity to dinitrochlorobenzene (DNCB) in guinea-pigs by dinitrophenyl-amino acids.二硝基苯基氨基酸对豚鼠诱导产生对二硝基氯苯（DNCB）的接触性超敏反应
Int Arch Allergy Appl Immunol. 1966;29(2):174-84. doi: 10.1159/000229698.
10
Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity.胸导管细胞的免疫能力。I. 迟发型超敏反应。
J Exp Med. 1966 Feb 1;123(2):267-81. doi: 10.1084/jem.123.2.267.
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