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[Studies on the analysis of nifedipine considering in particular transformation products formed by light exposition (author's transl)].

作者信息

Ebel S, Schütz H, Hornitschek A

出版信息

Arzneimittelforschung. 1978;28(12):2188-93.

PMID:582929
Abstract

Under the influence of light (VIS and UV) on thin-layer plates and in liquid solutions, 1,4-dihydro-2,6-dimethyl-4-(0-nitro-phenyl)-pyridine-3,5-carboxylic acid dimethylester (nifedipine, Adalat) is converted to the nitroso compound 4-(2-'nitrosophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-pyridine. The article also describes TLC-, GLC-, UV-, IR- and MS-data of nifedipine, the nitroso and the nitro derivative.

摘要

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