Speck U, Düsterberg B, Mannesmann G, Siefert H M
Arzneimittelforschung. 1978;28(12):2290-6.
The general, neural and cardiovascular tolerance of iotroxic acid (Biliscopin) and its deleterious effect on membranes were investigated in comparison with iodipamic- (Biligrafin), ioglycamic- (Biligram, Bilivistan) und iodoxamic acids in different experimental models. Tolerance (DL50) of iotroxic acid after i.v. injection in the rat proved to be significantly better than that of all the reference substances. The difference was most apparent in animals which had previously been given histamine. Neural tolerance was found to be best after iotroxic acid and iodipamic acid and poorest after iodoxamic acid. In in vitro investigations the erythrocyte membranes were far less damaged by iodoxamic acid and iotroxic acid than by iodipamic acid. Iotroxic acid was also particularly well tolerated after intracisternal injection and after injection into the carotid artery of the rat. The effect of iotroxic acid on the cardiovascular system of the cat was distinctly weaker than that of ioglycamic acid and, when given in high doses, evidently also weaker than that after administration of iodoxamic acid. The excellent general tolerance of iotroxic acid can be explained by the fact that its deleterious effect on membranes is less than that of iodipamic acid and that its neurotoxicity is distinctly lower than that of iodoxamic acid.
在不同实验模型中，将碘托酸（必利胆影）与碘番酸（胆影葡胺）、碘甘酸（胆影酸、必利维坦）和碘多酸进行比较，研究了碘托酸的一般耐受性、神经耐受性和心血管耐受性及其对细胞膜的有害作用。静脉注射后，大鼠对碘托酸的耐受性（半数致死量）明显优于所有参比物质。这种差异在预先给予组胺的动物中最为明显。发现碘托酸和碘番酸后的神经耐受性最佳，碘多酸后的神经耐受性最差。在体外研究中，碘多酸和碘托酸对红细胞膜的损伤远小于碘番酸。在脑池内注射和向大鼠颈动脉注射后，碘托酸的耐受性也特别好。碘托酸对猫心血管系统的作用明显弱于碘甘酸，高剂量给药时，显然也弱于碘多酸给药后的作用。碘托酸具有出色的一般耐受性，这可以解释为其对细胞膜的有害作用小于碘番酸，且其神经毒性明显低于碘多酸。
