Schriewer H, Weinhold F
Arzneimittelforschung. 1979;29(5):791-2.
In rat livers, removed 60 min after i.p. application of 150.6 mg/kg silybin-dihemisuccinate-di-Na-salt, in vitro incorporation of choline-(methyl-14C) into phosphatidyl choline by the postmitochondrial fraction of liver homogenates was enhanced in comparison with controls. These results are associated with increased activities of CTP-choline-phosphate cytidyltransferase. Enzyme activities were also enhanced after addition of 7.5 x 10(-6) mol/l silybin to incubation mixtures obtained from untreated rats.
在腹腔注射150.6mg/kg水飞蓟宾二半琥珀酸二钠盐60分钟后取出的大鼠肝脏中，与对照组相比，肝脏匀浆线粒体后部分将胆碱-（甲基-14C）体外掺入磷脂酰胆碱的过程增强。这些结果与CTP-胆碱-磷酸胞苷转移酶活性增加有关。在从未经处理的大鼠获得的孵育混合物中加入7.5×10（-6）mol/l水飞蓟宾后，酶活性也增强。
