[Increase in rat liver synthesis of fatty acids and glycerol phospholipids following parenteral application of silybin-dihemisuccinate].

1. 1 h after i.p. injection of 150.6 mg/kg silybin-dihemisuccinate the synthesis of fatty acids and glycerolipids was studied. 2. Measured as 3H incorporation after i.v. injection of 3H2O the synthesis of fatty acids was enhanced by silybin. Incorporation of [1-14C]-acetic acid in fatty acids of the postmitochondrial supernatant of liver homogenates was not influenced by silybin. The enhanced synthesis of fatty acids seems to be caused by an enhanced concentration of citrate, which was paralleled by a lowered pyruvate concentration and pyruvate-dehydrogenase activity. 3. In liver homogenates of silybin-treated animals the acylation of [U-14C]-glycerol-3-phosphate was increased as a measure of glycerolipid synthesis.