Ghinea E, Simionescu L, Oprescu M
Endocrinologie. 1979 Jul-Sep;17(3):185-90.
The action of aminotriasole (amitrol) and atrazine in doses of 0.001--1 mg and 0.0001--.01 mg/1.5 ml medium, respectively, upon cell cultures of human thyroid was studied in order to find out their influence on cell multiplication, proteic synthesis, enzymatic activity of thyroid cells, and hormonal synthesis. The results varied according to the dose utilized and the type of thyroid cell studied. The acute experiment carried out on rats treated 15 days with 500 ppm amitol and 50 ppm atrazine revealed variations in the T3, T4 and LH synthesis. Amitrol showed a strong inhibitory action on T3 and T4 secretion, whereas atrazine stimulated it.
研究了氨基三唑（杀草强）和阿特拉津分别以0.001--1毫克和0.0001--0.01毫克/1.5毫升培养基的剂量作用于人甲状腺细胞培养物，以查明它们对细胞增殖、蛋白质合成、甲状腺细胞酶活性和激素合成的影响。结果因所用剂量和所研究的甲状腺细胞类型而异。对用500 ppm杀草强和50 ppm阿特拉津处理15天的大鼠进行的急性实验显示，T3、T4和LH合成有变化。杀草强对T3和T4分泌有强烈抑制作用，而阿特拉津则刺激其分泌。
