Lundquist F, Tygstrup N, Winkler K, Jensen K B
Science. 1965 Oct 29;150(3696):616-7. doi: 10.1126/science.150.3696.616.
Glycerol is metabolized predominantly in the liver, the first step presumably being phosphorylation to alpha-glycerophosphate. When ethanol is present in the blood the rate of glycerol uptake by the splanchnic organs is reduced to about one-third of the control value. At the same time glycerophosphate accumulates in the liver. Hepatic blood flow and oxygen consumption are not influenced by the combined infusion of glycerol and ethanol. The phenomenon may be connected with the increased concentration of the reduced form of diphosphopyridine nucleotide present in the liver during ethanol metabolism.
甘油主要在肝脏中代谢，第一步可能是磷酸化生成α-甘油磷酸。当血液中存在乙醇时，内脏器官对甘油的摄取率降低至对照值的约三分之一。与此同时，甘油磷酸在肝脏中积累。甘油和乙醇联合输注不会影响肝血流量和耗氧量。这种现象可能与乙醇代谢过程中肝脏中存在的还原型二磷酸吡啶核苷酸浓度增加有关。
