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利多卡因与希氏束期前收缩。希氏束放电可伴有功能性右束支或左束支传导阻滞,或完全阻滞(隐匿性)。

Lidocaine and His bundle extrasystoles. His bundle discharge conducted with functional right of left bundle-branch block, or blocked entirely (concealed).

作者信息

Bonner A J, Zipes D P

出版信息

Arch Intern Med. 1976 Jun;136(6):700-4. doi: 10.1001/archinte.136.6.700.

Abstract

In this patient, discharge from the bundle of His either conducted normally, conducted with functional right or functional left bundle-branch block, or blocked entirely (concealed), depending on the preceding cycle length and the coupling interval of the premature His bundle depolarization. The presence of both functional right and left bundle-branch block may have been attributable to differences in effective and functional refractory periods between the two bundle branches. Concealed His bundle extrasystoles mimicked first-degree, and types I and II second-degree AV block, according to the interval between His bundle discharge and the subsequent P wave. Lidocaine eliminated His bundle extrasystoles that blocked entirely (concealed) or conducted with functional left bundle-branch block by improving His-Purkinje conduction and by lengthening the coupling interval of the premature His bundle extrasystole. Lidocaine had no effect on AV nodal conduction time. This patient has been known to have concealed His bundle discharge for at least three years and has not required permanent pacemaker insertion.

摘要

在该患者中,希氏束的激动传导情况各异,要么正常传导,要么表现为功能性右束支或左束支传导阻滞,或者完全阻滞(隐匿性),这取决于前一心动周期的长度以及提前出现的希氏束去极化的联律间期。功能性右束支和左束支传导阻滞同时存在,可能是由于两支束支在有效不应期和功能不应期方面存在差异。隐匿性希氏束期前收缩根据希氏束激动与随后P波之间的间期,可模拟一度、I型和II型二度房室传导阻滞。利多卡因通过改善希氏-浦肯野系统传导以及延长提前出现的希氏束期前收缩的联律间期,消除了完全阻滞(隐匿性)或伴有功能性左束支传导阻滞的希氏束期前收缩。利多卡因对房室结传导时间无影响。已知该患者存在隐匿性希氏束激动至少三年,且无需植入永久性起搏器。

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Combined intra-Hisian block and A-V nodal bypass.希氏束内阻滞与房室结旁路联合应用
J Electrocardiol. 1978 Jan;11(1):75-80. doi: 10.1016/s0022-0736(78)80033-8.

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