Mayo J B, McCarthy L R
Antimicrob Agents Chemother. 1977 May;11(5):844-7. doi: 10.1128/AAC.11.5.844.
Fifty random clinical isolates of Haemophilus parainfluenzae were tested for their susceptibility to 10 antibiotics by a microtiter broth dilution method. Three of the strains tested were resistant to ampicillin, whereas eight were resistant to tetracycline. All strains tested were susceptible to chloramphenicol, kanamycin, gentamicin, cephalothin, and colistin. The ranges of minimal inhibitory concentrations for the three remaining antibiotics were: 0.5 to >/=128 mug of penicillin G per ml, 0.03 to 4 mug of carbenicillin per ml, and 1 to 16 mug of erythromycin per ml. Elevated minimal inhibitory concentrations for penicillin and carbenicillin were noted for the three ampicillin-resistant strains. Tests for beta-lactamase production demonstrated the presence of this enzyme in each of the three ampicillin-resistant strains.
采用微量肉汤稀释法对50株副流感嗜血杆菌临床随机分离株进行了10种抗生素的敏感性检测。检测的菌株中有3株对氨苄西林耐药，8株对四环素耐药。所有检测菌株对氯霉素、卡那霉素、庆大霉素、头孢噻吩和黏菌素敏感。其余3种抗生素的最低抑菌浓度范围为：每毫升青霉素G 0.5至≥128微克，每毫升羧苄西林0.03至4微克，每毫升红霉素1至16微克。3株氨苄西林耐药菌株的青霉素和羧苄西林最低抑菌浓度升高。β-内酰胺酶产生检测表明，3株氨苄西林耐药菌株均存在该酶。
