Kan'shina N F, Figurnov V A, Korolev R V, Kryzhanovskiĭ V I
Arkh Patol. 1976 Apr;38(4):32-7.
Data on morphology of the kidneys in hemorrhagic fever with the renal syndrome (HFRS) are discussed. In the kidneys of 10 decreased patients (with time period from the onset of the disease till death 4--13 days), in whom the disease proceeded with azotemia and oligo-anuria, there were observed oligemia of the glomeruli with secondary changes in the cellular elements, dystrophic changes in the tubules, these changes being particularly pronounced in the proximal segment, and being accompanied by nephrohydrosis; beginning with the 4--6th day signs of regeneration, edema in the walls of vessels and swelling of a hypoxic character were noted. A distinguishing feature of HFRS was a drastic plethora of the jextamedullar zone with hemorrhages due to venous congestion. The changes in the kidneys observed in HFRS were similar to morphological changes in acute renal insufficiency (ARI) of the type of "shock kidney". A characteristic feature of API in HFRS was a high degree of sequestration of the blood flow in the medullar layer.
本文讨论了肾综合征出血热（HFRS）患者肾脏的形态学数据。对10例死亡患者（病程从发病至死亡为4 - 13天）的肾脏进行观察，这些患者伴有氮质血症和少尿 - 无尿，观察到肾小球缺血，细胞成分出现继发性改变，肾小管发生营养不良性改变，尤以近端小管段更为明显，并伴有肾盂积水；从第4 - 6天开始出现再生迹象，血管壁水肿以及缺氧性肿胀。HFRS的一个显著特征是由于静脉淤血导致肾髓质外层出现严重充血并伴有出血。HFRS患者肾脏的变化类似于“休克肾”型急性肾功能不全（ARI）的形态学变化。HFRS中急性肾功能不全的一个特征是髓质层血流高度淤滞。
