Werneck L C, Hatschbach Z, Mora A H, Novak E M
Arq Neuropsiquiatr. 1977 Dec;35(4):366-72. doi: 10.1590/s0004-282x1977000400010.
The case of a 17 years-old woman, with clinical findings of meningites, without identification of a pathogenic agent is reported. The pacient received treatment for tuberculous and fungi meningitis. In the clinical course were found neoplastic cells in the spinal fluid. Despite the radiologic investigation, the original site of the tumor was not found in life. In the post-mortem examination, a small tumor was discovered in the 4th ventricle. The hystologic examination revealed a primary central nervous system lymphoma, diffuse infiltration of the meninges by tumor cells and proliferation into the central nervous system through the Virchow-Robin space. The clinical course, laboratory investigation and anatomical findings of the tumor are presented. A short revision about the pathogenesis of neoplastic meningites and primary central nervous system lymphoma is made.
报告了一名17岁女性的病例，其临床表现为脑膜炎，但未鉴定出病原体。该患者接受了结核性和真菌性脑膜炎的治疗。在临床病程中，脑脊液中发现了肿瘤细胞。尽管进行了放射学检查，但生前未发现肿瘤的原发部位。尸检时，在第四脑室发现了一个小肿瘤。组织学检查显示为原发性中枢神经系统淋巴瘤，肿瘤细胞弥漫性浸润脑膜并通过Virchow-Robin间隙向中枢神经系统增殖。介绍了该肿瘤的临床病程、实验室检查及解剖学发现。对肿瘤性脑膜炎和原发性中枢神经系统淋巴瘤的发病机制进行了简要回顾。
