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辐照对无毒力的Semliki森林病毒诱导的脱髓鞘作用的影响。

The effect of irradiation on demyelination induced by avirulent Semliki Forest virus.

作者信息

Chew-Lim M, Webb H E, Jagelman S

出版信息

Br J Exp Pathol. 1977 Oct;58(5):459-64.

PMID:588439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041266/
Abstract

A dose of 500 rad total body irradiation before Semliki Forest virus infection was the most effective in producing multiple foci of demyelination in Swiss mice. Animals receiving this dose had the highest virus titre of Semliki Forest virus persisting in the brain and a delayed antibody response. In spite of extensive demyelination no obvious clinical signs such as paralysis were observed.

摘要

在感染Semliki森林病毒之前进行500拉德的全身照射剂量，对在瑞士小鼠中产生多个脱髓鞘病灶最为有效。接受此剂量的动物，其脑中持续存在的Semliki森林病毒的病毒滴度最高，且抗体反应延迟。尽管有广泛的脱髓鞘现象，但未观察到明显的临床症状，如瘫痪。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1a4/2041266/9766cb4f98a5/brjexppathol00137-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1a4/2041266/3080c58a7428/brjexppathol00137-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1a4/2041266/9766cb4f98a5/brjexppathol00137-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1a4/2041266/3080c58a7428/brjexppathol00137-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1a4/2041266/9766cb4f98a5/brjexppathol00137-0006-b.jpg

相似文献

1
The effect of irradiation on demyelination induced by avirulent Semliki Forest virus.辐照对无毒力的Semliki森林病毒诱导的脱髓鞘作用的影响。
Br J Exp Pathol. 1977 Oct;58(5):459-64.
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引用本文的文献

1
Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS.塞姆利基森林病毒感染小鼠的重建会在中枢神经系统中引发免疫介导的病理变化。
Clin Exp Immunol. 1983 Apr;52(1):115-20.
2
Demyelination in mice resulting from infection with a mutant of Semliki Forest virus.感染塞姆利基森林病毒突变体导致小鼠脱髓鞘。
Acta Neuropathol. 1981;53(2):129-36. doi: 10.1007/BF00689993.
3
Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation.塞姆利基森林病毒诱导的免疫介导性脱髓鞘：辐射的影响

本文引用的文献

1
Studies on the nature of the nature of the neutralization reaction and the competition for neutralizing antibody between components of the virus system of foot-and-mouth disease.口蹄疫病毒系统各组分间中和反应的性质及中和抗体竞争的研究。
Virology. 1962 Nov;18:378-400. doi: 10.1016/0042-6822(62)90029-6.
2
A method for the combined staining of cells and fibers in the nervous system.一种用于神经系统中细胞和纤维联合染色的方法。
J Neuropathol Exp Neurol. 1953 Oct;12(4):400-3. doi: 10.1097/00005072-195312040-00008.
3
The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits.
Br J Exp Pathol. 1987 Feb;68(1):101-13.
4
CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus).塞姆利基森林病毒（甲病毒属）和兰加特病毒（黄病毒属）双重病毒感染后的中枢神经系统发病机制。
Br J Exp Pathol. 1988 Apr;69(2):197-208.
5
Brain viral persistence and myelin damage in nude mice.裸鼠的脑病毒持续性与髓鞘损伤
Can J Comp Med. 1979 Jan;43(1):39-43.
塞姆利基森林病毒原始株及衍生株对小鼠、豚鼠和兔子的毒力。
J Gen Virol. 1971 Aug;12(2):141-60. doi: 10.1099/0022-1317-12-2-141.
4
Immunosuppression: a means to assess the role of the immune response in acute virus infections.免疫抑制：一种评估免疫反应在急性病毒感染中作用的手段。
Fed Proc. 1971 Nov-Dec;30(6):1822-30.
5
Langat virus encephalitis in mice. II. The effect of irradiation.小鼠中的兰加特病毒脑炎。II. 辐射的影响。
J Hyg (Lond). 1968 Sep;66(3):355-64. doi: 10.1017/s002217240004122x.
6
Maintenance of latent herpetic infection: an apparent role for anti-viral IgG.潜伏性疱疹感染的维持：抗病毒IgG的明显作用。
J Immunol. 1974 Dec;113(6):1685-93.
7
Brain lysosomal glycosidase activity in immunosuppressed mice infected with avirulent Semliki forest virus.感染无毒力塞姆利基森林病毒的免疫抑制小鼠的脑溶酶体糖苷酶活性
Infect Immun. 1977 Feb;15(2):386-91. doi: 10.1128/iai.15.2.386-391.1977.
8
Response of irradiated mice to live-virus (TC-83) immunization.受辐照小鼠对活病毒（TC-83）免疫的反应。
Infect Immun. 1975 Mar;11(3):481-7. doi: 10.1128/iai.11.3.481-487.1975.