辐照对无毒力的Semliki森林病毒诱导的脱髓鞘作用的影响。
The effect of irradiation on demyelination induced by avirulent Semliki Forest virus.
作者信息
Chew-Lim M, Webb H E, Jagelman S
出版信息
Br J Exp Pathol. 1977 Oct;58(5):459-64.
Abstract
A dose of 500 rad total body irradiation before Semliki Forest virus infection was the most effective in producing multiple foci of demyelination in Swiss mice. Animals receiving this dose had the highest virus titre of Semliki Forest virus persisting in the brain and a delayed antibody response. In spite of extensive demyelination no obvious clinical signs such as paralysis were observed.
摘要
在感染Semliki森林病毒之前进行500拉德的全身照射剂量，对在瑞士小鼠中产生多个脱髓鞘病灶最为有效。接受此剂量的动物，其脑中持续存在的Semliki森林病毒的病毒滴度最高，且抗体反应延迟。尽管有广泛的脱髓鞘现象，但未观察到明显的临床症状，如瘫痪。
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