左心室转流期间在犬身上研究前列腺素内过氧化物类似物的循环效应。
Circulatory effects of prostaglandin endoperoxide analogues studied in the dog during left ventricular bypass.
作者信息
Alter I, Kot P A, Ramwell P W, Rose J C, Shnider M R
出版信息
Br J Pharmacol. 1977 Nov;61(3):395-8. doi: 10.1111/j.1476-5381.1977.tb08431.x.
Abstract
- Intravenous administration of both the 9alpha,11alpha-(epoxymethano) and 11alpha,9alpha-(epoxymethano) analogues of prostaglandin H2 (0.25 microgram/kg) produced a prominent rise in pulmonary arterial pressure and a moderate increase in systemic arterial pressure. 2. Direct administration of the endoperoxide analogues (1.25 microgram/kg) into the bypass reservoir produced a greater rise in systemic arterial pressure and less prominent rise in pulmonary arterial pressure. 3. An intravenous dose of prostaglandin F2alpha that was 20 times larger was needed to produce a comparable rise in pulmonary arterial pressure. 4. The pulmonary and systemic pressor responses produced by the endoperoxide analogues were due to a direct increase in the vascular resistance.
摘要
- 静脉注射前列腺素H2的9α,11α-(环氧亚甲基)和11α,9α-(环氧亚甲基)类似物（0.25微克/千克）可使肺动脉压显著升高，体动脉压适度升高。2. 将内过氧化物类似物（1.25微克/千克）直接注入旁路储液器可使体动脉压升幅更大，肺动脉压升幅则不那么显著。3. 需要20倍剂量的静脉注射前列腺素F2α才能产生相当的肺动脉压升高。4. 内过氧化物类似物引起的肺和体循环升压反应是由于血管阻力直接增加所致。
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