Adair H M
Br J Surg. 1977 Nov;64(11):800-4. doi: 10.1002/bjs.1800641113.
Certain features of epidermal repair, namely increased mitotic activity, cell migration and cell differentiation, have been investigated in fresh biopsies from 17 patients with chronic venous ulcers, using light and electron microscopy. Increased mitotic activity was present at the edges of most of these lesions whether they were in a grossly recognizable healing or non-healing phase, and some cells with ultrastructural features of migratory cells were invariably seen. The results are discussed in relation to other chronic epithelial lesions and suggest that failure of epithelialization is not due to any lack of epithelial cell production and that some other fundamental defect must be sought.
利用光学显微镜和电子显微镜，对17例慢性静脉溃疡患者的新鲜活检组织进行研究，观察了表皮修复的某些特征，即有丝分裂活性增加、细胞迁移和细胞分化。在大多数这些病变的边缘均存在有丝分裂活性增加的情况，无论它们处于肉眼可辨别的愈合期还是非愈合期，并且总是能看到一些具有迁移细胞超微结构特征的细胞。本文结合其他慢性上皮病变对结果进行了讨论，结果表明上皮形成失败并非由于上皮细胞产生不足，而必须寻找其他一些根本性缺陷。
