用于患者淋巴细胞迁移研究的放射性标记物的实验比较。
An experimental comparison of radioactive labels with potential application to lymphocyte migration studies in patients.
作者信息
Rannie G H, Thakur M L, Ford W L
出版信息
Clin Exp Immunol. 1977 Sep;29(3):509-14.
Abstract
The suitability of two radionuclides (99mTc, 111In) for labelling lymphocytes have been evaluated in rats by comparison with a standard method using 51Cr. For the study of lymphocyte migration in patients labelling with 111In-labelled oxine is clearly the most promising because both in vivo and in vitro it remains associated with lymphocytes and the labelled cells migrate normally into lymphoid tissues. The physical characteristics of 111In are also favourable. Not only does 99mTc rapidly dissociate from lymphocytes but also it compromises their ability to recirculate from blood to lymph.
摘要
通过与使用51Cr的标准方法比较，在大鼠中评估了两种放射性核素（99mTc、111In）标记淋巴细胞的适用性。对于研究患者体内淋巴细胞迁移，用111In标记的喹啉显然是最有前景的，因为无论在体内还是体外，它都能与淋巴细胞结合，且标记后的细胞能正常迁移至淋巴组织。111In的物理特性也很有利。99mTc不仅会迅速从淋巴细胞上解离，还会损害其从血液再循环至淋巴的能力。
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