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1
In vitro studies on radiation lymphoid recovery of mouse spleen.小鼠脾脏辐射后淋巴细胞恢复的体外研究。
J Exp Med. 1966 Jan 1;123(1):25-32. doi: 10.1084/jem.123.1.25.
2
Studies on the relationship between thymus regeneration and lymphoma prevention in C57Bl-6 mice irradiated and injected with syngeneic spleen cells.对经照射并注射同基因脾细胞的C57Bl-6小鼠胸腺再生与淋巴瘤预防之间关系的研究。
Int J Cancer. 1971 May 15;7(3):491-8. doi: 10.1002/ijc.2910070315.
3
[Influence of thymectomy on the lymphoid regeneration of hematopoietic bone marrow after sublethal irradiation].[胸腺切除对亚致死剂量照射后造血骨髓淋巴样再生的影响]
C R Seances Soc Biol Fil. 1976 Oct;170(3):698-702.
4
Regeneration of the spleen, thymus and femoral bone marrow following irradiation of diethyldithiocarbamate-protected mice.二乙氨基二硫代甲酸盐保护的小鼠受照射后脾脏、胸腺和股骨骨髓的再生
Radiobiol Radiother (Berl). 1988;29(4):409-16.
5
[Recovery of hematopoiesis in mice following a continuous irradiation with a dose rate of 0.957 Gy/d and a total accumulated dose of 19.14 Gy. I. Bone marrow, spleen and thymus gland].[以0.957 Gy/d的剂量率连续照射且总累积剂量为19.14 Gy后小鼠造血功能的恢复。I. 骨髓、脾脏和胸腺]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(4):564-71.
6
Lymphoid tissues induce NGF-dependent and NGF-independent neurite outgrowth from rat superior cervical ganglia explants in culture.淋巴组织可诱导培养的大鼠颈上神经节外植体长出依赖神经生长因子（NGF）和不依赖神经生长因子的神经突。
J Neurosci Res. 1994 Feb 15;37(3):374-83. doi: 10.1002/jnr.490370309.
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[Influence of the thymus gland on lymphoid regeneration in the rat after administration of lethal doses of myleran and a marrow graft].[给予致死剂量马利兰及骨髓移植后胸腺对大鼠淋巴组织再生的影响]
Pathol Biol (Paris). 1969 Apr;17(7):365-9.
8
Clonal repopulation in reticular tissues of x-irradiated mice: effect of dose and limb-shielding.X射线照射小鼠网状组织中的克隆性再增殖：剂量和肢体屏蔽的影响。
J Cell Physiol. 1967 Aug;70(1):37-44. doi: 10.1002/jcp.1040700106.
9
[STUDY OF LATE MORTALITY, OF LYMPHOID REGENERATION AND OF THE IMMUNOLOGICAL REACTIVITY OF IRRADIATED THYMIPRIVIC MICE RESTORED BY FETAL LIVER, BONE MARROW OR ISOGENIC SPLEEN].[经胎儿肝脏、骨髓或同基因脾脏恢复的胸腺缺失小鼠的晚期死亡率、淋巴再生及免疫反应性研究]
C R Seances Soc Biol Fil. 1963 Nov 15;157:1211-6.
10
[Dynamic and dose-related characteristics of the process of lymphoid tissue depletion in irradiated rodents].[受辐照啮齿动物淋巴组织耗竭过程的动态及剂量相关特征]
Radiobiologiia. 1974 May-Jun;14(3):409-12.

引用本文的文献

1
Reactivation in vitro of immunocompetence in irradiated mouse spleen.照射鼠脾免疫活性的体外再激活。
J Exp Med. 1967 Aug 1;126(2):223-34. doi: 10.1084/jem.126.2.223.
2
Primary antibody response in organ cultures.器官培养中的初次抗体反应。
J Exp Med. 1966 Nov 1;124(5):1001-16. doi: 10.1084/jem.124.5.1001.
3
In vitro and in vivo studies of the immune response to sheep erythrocytes using partially purified cell preparations.使用部分纯化的细胞制剂对绵羊红细胞免疫反应的体外和体内研究。
J Exp Med. 1970 Jan 1;131(1):57-76. doi: 10.1084/jem.131.1.57.

本文引用的文献

1
Increase in incidence of leukemia in hybrid mice bearing thymic transplants from a high leukemic strain.接受来自高白血病发病率品系的胸腺移植的杂交小鼠白血病发病率增加。
J Natl Cancer Inst. 1952 Feb;12(4):789-805.
2
IMMUNOLOGIC ROLE OF THE THYMUS IN RADIATION CHIMERAS.胸腺在辐射嵌合体中的免疫作用
Ann N Y Acad Sci. 1964 Nov 30;120:205-17. doi: 10.1111/j.1749-6632.1964.tb34718.x.
3
THE ROLE OF THE THYMUS IN RESTORING IMMUNOLOGICAL REACTIVITY AND LYMPHOID CELL DIFFERENTIATION IN X-IRRADIATED ADULT MICE.胸腺在恢复受X射线照射的成年小鼠免疫反应性及淋巴细胞分化中的作用
Ann N Y Acad Sci. 1964 Nov 30;120:182-90. doi: 10.1111/j.1749-6632.1964.tb34716.x.
4
STEM CELL REPLACEMENT IN NORMAL THYMUS GRAFTS.正常胸腺移植中的干细胞替代
Proc Soc Exp Biol Med. 1964 Mar;115:731-5. doi: 10.3181/00379727-115-29022.
5
ROLE OF THE THYMUS IN RESTORATION OF IMMUNE REACTIVITY AND LYMPHOID REGENERATION IN IRRADIATED MICE.胸腺在受辐照小鼠免疫反应性恢复及淋巴组织再生中的作用
Transplantation. 1964 Mar;2:212-27. doi: 10.1097/00007890-196403000-00006.
6
ACTIVITY OF A NONCELLULAR CALF THYMUS EXTRACT IN NORMAL AND THYMECTOMIZED MICE.一种无细胞小牛胸腺提取物在正常小鼠和胸腺切除小鼠中的活性
Life Sci (1962). 1963 Nov;11:810-9. doi: 10.1016/0024-3205(63)90091-2.
7
EVIDENCE FOR A HUMORAL THYMUS FACTOR RESPONSIBLE FOR THE MATURATION OF IMMUNOLOGICAL FACULTY.一种负责免疫功能成熟的体液胸腺因子的证据。
Nature. 1963 Aug 17;199:653-4. doi: 10.1038/199653a0.
8
EVIDENCE FOR FUNCTION OF THYMIC TISSUE IN DIFFUSION CHAMBERS IMPLANTED IN NEONATALLY THYMECTOMIZED MICE. PRELIMINARY REPORT.植入新生期切除胸腺小鼠扩散盒中的胸腺组织功能的证据。初步报告。
J Natl Cancer Inst. 1963 Aug;31:199-217.
9
Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells.移植小鼠骨髓细胞来源的脾集落克隆性质的细胞学证明。
Nature. 1963 Feb 2;197:452-4. doi: 10.1038/197452a0.
10
Thymus: its role in lymphoid recovery after irradiation.胸腺：其在辐射后淋巴细胞恢复中的作用。
Science. 1963 Mar 15;139(3559):1061. doi: 10.1126/science.139.3559.1061.

小鼠脾脏辐射后淋巴细胞恢复的体外研究。

In vitro studies on radiation lymphoid recovery of mouse spleen.

作者信息

Globerson A

出版信息

J Exp Med. 1966 Jan 1;123(1):25-32. doi: 10.1084/jem.123.1.25.

DOI:10.1084/jem.123.1.25
PMID:5902570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138127/
Abstract

In vitro studies, utilizing an organ culture method were reported on mutual interactions between irradiated spleen, normal bone marrow, and thymus. It has been shown; (a) that singly isolated spleen explants were incapable of lymphoid regeneration, (b) thymus had no stimulatory effect on spleen regeneration, (c) bone marrow interacted synergistically with spleen leading to appearance of lymphoid cells which were not detected in singly isolated bone marrow or spleen, and (d) no stimulation of lymphopoiesis in bone marrow was conferred by thymus in the absence of spleen. The results are discussed in terms of possible mechanisms involved in lymphoid radiation recovery in vivo.

摘要

利用器官培养方法进行的体外研究报道了受辐照脾脏、正常骨髓和胸腺之间的相互作用。结果表明：（a）单独分离的脾脏外植体无法进行淋巴样再生；（b）胸腺对脾脏再生没有刺激作用；（c）骨髓与脾脏协同相互作用，导致出现了在单独分离的骨髓或脾脏中未检测到的淋巴细胞；（d）在没有脾脏的情况下，胸腺不会刺激骨髓中的淋巴细胞生成。根据体内淋巴样辐射恢复可能涉及的机制对结果进行了讨论。