小鼠脾脏辐射后淋巴细胞恢复的体外研究。
In vitro studies on radiation lymphoid recovery of mouse spleen.
作者信息
Globerson A
出版信息
J Exp Med. 1966 Jan 1;123(1):25-32. doi: 10.1084/jem.123.1.25.
Abstract
In vitro studies, utilizing an organ culture method were reported on mutual interactions between irradiated spleen, normal bone marrow, and thymus. It has been shown; (a) that singly isolated spleen explants were incapable of lymphoid regeneration, (b) thymus had no stimulatory effect on spleen regeneration, (c) bone marrow interacted synergistically with spleen leading to appearance of lymphoid cells which were not detected in singly isolated bone marrow or spleen, and (d) no stimulation of lymphopoiesis in bone marrow was conferred by thymus in the absence of spleen. The results are discussed in terms of possible mechanisms involved in lymphoid radiation recovery in vivo.
摘要
利用器官培养方法进行的体外研究报道了受辐照脾脏、正常骨髓和胸腺之间的相互作用。结果表明：（a）单独分离的脾脏外植体无法进行淋巴样再生；（b）胸腺对脾脏再生没有刺激作用；（c）骨髓与脾脏协同相互作用，导致出现了在单独分离的骨髓或脾脏中未检测到的淋巴细胞；（d）在没有脾脏的情况下，胸腺不会刺激骨髓中的淋巴细胞生成。根据体内淋巴样辐射恢复可能涉及的机制对结果进行了讨论。
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