Reynolds L M, Dyer R G, Jenner P, Marsden C D
J Pharm Pharmacol. 1983 Mar;35(3):170-4. doi: 10.1111/j.2042-7158.1983.tb04299.x.
Hypophysectomy is claimed to prevent increased forebrain dopamine turnover produced by administration of sulpiride. We have measured the increase in dopamine metabolite concentrations caused by sulpiride following surgical removal of the pituitary. In saline-treated control animals and in hypophysectomized rats 1 week or 1 month following surgery, administration of sulpiride caused marked elevations of striatal, nucleus accumbens and tuberculum olfactorium, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations which were maximal 4-8 h following drug administration. The maximal increases in nucleus accumbens and tuberculum olfactorium were generally comparable in control and hypophysectomized animals, except for a greater increase in HVA levels in the nucleus accumbens 1 month following hypophysectomy. However, maximal increases in HVA and DOPAC in striatum were more pronounced in hypophysectomized rats 1 week or 1 month following surgery compared with control animals. At 30 min following sulpiride administration only inconsistent changes in dopamine turnover were observed in both control and hypophysectomized rats. Hypophysectomy does not prevent sulpiride from increasing forebrain dopamine turnover suggesting this is due to a direct interaction with cerebral dopamine receptors.
垂体切除术据称可防止因给予舒必利而导致的前脑多巴胺周转率增加。我们测量了垂体手术切除后舒必利引起的多巴胺代谢物浓度的增加。在生理盐水处理的对照动物以及术后1周或1个月的垂体切除大鼠中，给予舒必利会导致纹状体、伏隔核和嗅结节、高香草酸（HVA）和3,4 - 二羟基苯乙酸（DOPAC）浓度显著升高，在给药后4 - 8小时达到最大值。除了垂体切除术后1个月伏隔核中HVA水平的增加更大外，对照动物和垂体切除动物中伏隔核和嗅结节的最大增加通常相当。然而，与对照动物相比，术后1周或1个月的垂体切除大鼠纹状体中HVA和DOPAC的最大增加更为明显。在给予舒必利后30分钟，对照和垂体切除大鼠中仅观察到多巴胺周转率的不一致变化。垂体切除术不能阻止舒必利增加前脑多巴胺周转率，表明这是由于与脑多巴胺受体的直接相互作用。
