Pierpaoli W
Experientia. 1977 Dec 15;33(12):1612-4. doi: 10.1007/BF01934028.
The maintainance of mice on a reduced caloric diet for 6 weeks starting from weaning time produces persistent changes in their hormonal status as reflected by differences in blood levels of gonadal and adrenal steroids. The changes might express a permanently different hypothalamic regulation. This might account for a prolongation of their life span.
从断奶期开始,让小鼠持续6周摄入低热量饮食,会使其激素状态发生持续性变化,这可通过性腺和肾上腺类固醇的血液水平差异反映出来。这些变化可能表明下丘脑调节出现了永久性差异。这或许可以解释它们寿命的延长。