体外抑制精子通过宫颈黏液的迁移。

Inhibition of sperm migration through cervical mucus in vitro.

作者信息

Lorton S P, First N L

出版信息

Fertil Steril. 1977 Dec;28(12):1295-1300. doi: 10.1016/s0015-0282(16)42972-9.

Abstract

The effectiveness of inhibiting bovine sperm migration through cervical mucus in vitro by prior treatment of semen with 45 to 150 micrograms of soybean trypsin inhibitor, univalent (papain-digested, nonagglutinating) and bivalent (undigested) rabbit anti-bovine sperm immunoglobulin, and heat-treated heifer serum was studied. Sperm head-to-head agglutination resulted from treatment of semen with bivalent immune antibody and heat-treated heifer serum. Migration through cervical mucus was inhibited only by treatment resulting in spermagglutination. It is postulated that in vivo inhibition of sperm migration may be influenced by secretory immunoglobulins from the cervix.

摘要

研究了用45至150微克大豆胰蛋白酶抑制剂、单价（木瓜蛋白酶消化的、非凝集性的）和双价（未消化的）兔抗牛精子免疫球蛋白以及热处理的小母牛血清对精液进行预处理，在体外抑制牛精子通过宫颈黏液迁移的效果。用双价免疫抗体和热处理的小母牛血清处理精液会导致精子头对头凝集。只有导致精子凝集的处理才能抑制精子通过宫颈黏液的迁移。据推测，体内精子迁移的抑制可能受宫颈分泌的免疫球蛋白影响。