Chattopadhyay D K, Greaney M G, Irvin T T
Gut. 1977 Oct;18(10):833-5. doi: 10.1136/gut.18.10.833.
Observations on the effect of smoking on lower oesophageal sphincter pressure (LOSP) are based on station pull-through techniques of eosophageal manometry and recent studies have suggested that these techniques are inaccurate. Reproducible measurements of LOSP may be achieved with a rapid pull-through (RPT) method of manometry. This method was used to determine the effect of cigarette smoking on LOSP in 10 asymptomatic volunteers and in a group of 10 patients with symptoms of gastro-oesophageal reflux. Basal LOSP measurements in the two groups were not significantly different but LOSP was reduced by 19% in asymptomatic subjects (p less than 0-01) and by 21% in symptomatic patients (p less than 0-02) during cigarette smoking. The results suggest that smoking should be avoided in the clinical management of gastro-oesophageal reflux.
关于吸烟对食管下括约肌压力（LOSP）影响的观察结果是基于食管测压的牵拉通过技术，而最近的研究表明这些技术并不准确。通过测压的快速牵拉通过（RPT）方法可以实现对LOSP的可重复测量。该方法用于确定吸烟对10名无症状志愿者和10名有胃食管反流症状患者的LOSP的影响。两组的基础LOSP测量值无显著差异，但在吸烟期间，无症状受试者的LOSP降低了19%（p<0.01），有症状患者的LOSP降低了21%（p<0.02）。结果表明，在胃食管反流的临床管理中应避免吸烟。
