用对映体合成多肽免疫后抗体反应降低。
Decreased antibody response following immunization with enantiomorphic synthetic polypeptides.
作者信息
Gill T J, Kunz H W
出版信息
Int Arch Allergy Appl Immunol. 1977;55(1-6):293-6. doi: 10.1159/000231939.
PMID:591097
Abstract
The ability to decrease the antibody response to poly(Glu52Lys33Tyr15) in the DA and PVG strains of rats by prior immunization with its D-amino acid enantiomorph poly(DGlu48DLys38DTyr14) was tested as part of a continuing investigation into the role of optical isomerism in the ability of an antigen to induce an antibody response. The results showed that prior immunization with the D-amino acid polymer decreased the immune response to the isomeric L-polypeptide in both strains.
摘要
作为对光学异构在抗原诱导抗体反应能力中作用的持续研究的一部分，测试了通过预先用其D-氨基酸对映体聚（D-谷氨酸48-D-赖氨酸38-D-酪氨酸14）免疫来降低大鼠DA和PVG品系对聚（谷氨酸52-赖氨酸33-酪氨酸15）的抗体反应的能力。结果表明，预先用D-氨基酸聚合物免疫可降低两个品系对异构L-多肽的免疫反应。
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