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The synthesis and pharmacological activity of 5-ethyl-5-(3-hydroxy-1-methylbutyl)-barbituric acid.

作者信息

Dickert Y J, Shea P J, McCarty L P

出版信息

J Med Chem. 1966 Mar;9(2):249. doi: 10.1021/jm00320a026.

DOI:10.1021/jm00320a026
PMID:5911809
Abstract
摘要

相似文献

1
The synthesis and pharmacological activity of 5-ethyl-5-(3-hydroxy-1-methylbutyl)-barbituric acid.5-乙基-5-(3-羟基-1-甲基丁基)巴比妥酸的合成与药理活性
J Med Chem. 1966 Mar;9(2):249. doi: 10.1021/jm00320a026.
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A study of the excitatory effects of barbiturates.
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Convulsant, anticonvulsant and anaesthetic barbiturates. 5-Ethyl-5-(3'-methyl-but-2'-enyl)-barbituric acid and related compounds.惊厥剂、抗惊厥剂和麻醉性巴比妥酸盐。5-乙基-5-(3'-甲基-丁-2'-烯基)-巴比妥酸及相关化合物。
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A racemic form of 5-ethyl-5-(3-hydroxy-1-methylbutyl)barbituric acid as a metabolite of pentobarbital.
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Resolution of optical isomers of 5-allyl-5-(beta-hydroxypropyl)-barbituric acid (Ipronal, Axeen) and their pharmacological activity.
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[Historical points in the field of organic chemistry. II. Origin of the names given to compounds of the uric acid group by early authors; etymology of the term barbituric acid].[有机化学领域的历史要点。二。早期作者赋予尿酸类化合物的名称的起源;巴比妥酸一词的词源]
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Calcium uptake mechanisms affected by some convulsant and anticonvulsant drugs.
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THE METABOLIC FATE OF 5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID (SECOBARBITAL).5-烯丙基-5-(1-甲基丁基)巴比妥酸(司可巴比妥)的代谢命运
J Pharmacol Exp Ther. 1965 Jul;149:23-8.

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Pharmacodynamics and pharmacokinetics of thiopental.硫喷妥钠的药效学与药代动力学。
Clin Pharmacokinet. 1998 Aug;35(2):95-134. doi: 10.2165/00003088-199835020-00002.
2
Multidose studies in the human metabolism of pentobarbitone.戊巴比妥人体代谢的多剂量研究。
Eur J Drug Metab Pharmacokinet. 1980;5(2):75-80. doi: 10.1007/BF03189449.
3
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.由于用苯巴比妥和氯丙嗪处理哺乳期母鼠,导致乳鼠肝脏中药物代谢活性的变化。
Biochem J. 1971 Mar;122(1):41-7. doi: 10.1042/bj1220041.