Lanng Nielsen J, Amdisen A, Darling S, Pedersen E B
Neuropsychobiology. 1977;3(1):30-4. doi: 10.1159/000117586.
Plasma prolactin was determined in a longitudinal study, where -9 manic-depressive patients were examined before lithium treatment and at various times during the treatment with the aim of unravelling a possible association between initial changes in water and sodium balance during lithium treatment and changes in plasma prolactin level. No significant changes were found, nor could any correlation between serum lithium and plasma prolactin be established. Some reports have indicated association between breast cancer and prolonged elevated plasma prolactin, such as is seen during treatment with phenothiazines and reserpine. In a transversal study, determination of plasma prolactin during long-term lithium treatment in 26 patients did not reveal any elevation compared with 16 controls. Lithium is accordingly not among the drugs which produce prolonged elevation of plasma prolactin.
在一项纵向研究中测定了血浆催乳素水平。该研究对9名躁郁症患者在锂盐治疗前及治疗期间的不同时间进行了检查，目的是揭示锂盐治疗期间水和钠平衡的初始变化与血浆催乳素水平变化之间可能存在的关联。未发现显著变化，也未建立血清锂与血浆催乳素之间的相关性。一些报告表明乳腺癌与血浆催乳素长期升高有关，如在使用吩噻嗪类药物和利血平治疗期间所见。在一项横向研究中，对26例长期接受锂盐治疗的患者测定血浆催乳素，与16名对照组相比未发现任何升高。因此，锂盐不属于可导致血浆催乳素长期升高的药物。
