Moore S B, Goodwin F J
Lancet. 1976 Jul 10;2(7976):67-70. doi: 10.1016/s0140-6736(76)92287-x.
The effect of propranolol has been studied in two patients with chronic renal failure and hypertension which remained refractory despite the removal of excess sodium and water by dialysis. Measurements of plasma-renin, exchangeable sodium, and blood-volume demonstrated that in both patients hypertension was due to excess renin. The administration of propranolol was followed by a rapid fall in blood-pressure to normal, thereby obviating the need for bilateral nephrectomy. In both patients the fall in blood-pressure was accompanied by a striking fall in plasma-renin, and in one there was a highly significant association between plasma-renin activity and mean arterial pressure.
已对两名慢性肾衰竭合并高血压患者使用普萘洛尔的效果进行了研究。尽管通过透析去除了过多的钠和水，但他们的高血压仍难以控制。血浆肾素、可交换钠和血容量的测量结果表明，两名患者的高血压均由肾素过多所致。服用普萘洛尔后，血压迅速降至正常，从而避免了双侧肾切除术的必要性。两名患者血压下降的同时，血浆肾素也显著下降，其中一名患者的血浆肾素活性与平均动脉压之间存在高度显著的相关性。
