Sridaran R, Blake C A
J Endocrinol. 1980 Jan;84(1):75-82. doi: 10.1677/joe.0.0840075.
The effects of chronic adrenalectomy on the oestrous cycle, periovulatory gonadotrophin surges in sera and ovulation in the rat were assessed. Rats which were exposed to a 14 h light : 10 h darkness lighting schedule for at least 3 weeks and those which showed at least two consecutive 4 day oestrous cycles were divided into three groups. One group (controls) was left untreated. The rest were adrenalectomized (ADX) or sham-adrenalectomized (Sham) during oestrus and then placed in a different animal room with the same lighting schedule but with the onset and end of the photoperiod delayed by 4 h. These operations did not interrupt the length of the oestrous cycles. Rats were decapitated for collection of trunk blood on the fifth pro-oestrous or oestrous day after the operation. Both Sham and ADX rats synchronized to the new lighting schedule in terms of the temporal patterns of their periovulatory surges in serum LH and FSH and the timing of ovulation. Neither adrenalectomy nor the sham-operation altered the magnitude of the pro-oestrous or oestrous increases in serum LH or FSH when compared with those in control rats. Body, uterine and ovarian weights as well as the number of ova shed were similar in the ADX and Sham groups. The results indicate that adrenal secretions are not necessary for rats to synchronize the timing of the periovulatory surges in serum LH and FSH or ovulation to a 14 h light : 10 h darkness schedule and the periovulatory surges of LH and FSH are unaltered in chronically adrenalectomized rats.
评估了慢性肾上腺切除术对大鼠发情周期、血清中排卵前促性腺激素激增及排卵的影响。将暴露于14小时光照：10小时黑暗光照周期至少3周且表现出至少两个连续4天发情周期的大鼠分为三组。一组（对照组）不做处理。其余大鼠在发情期进行肾上腺切除（ADX）或假肾上腺切除（Sham），然后置于另一动物房，光照周期相同，但光周期的开始和结束延迟4小时。这些手术并未中断发情周期的长度。术后第五个动情前期或发情期，将大鼠断头以采集躯干血。Sham组和ADX组大鼠在血清LH和FSH排卵前激增的时间模式及排卵时间方面均与新的光照周期同步。与对照大鼠相比，肾上腺切除术和假手术均未改变动情前期或发情期血清LH或FSH的升高幅度。ADX组和Sham组大鼠的体重、子宫和卵巢重量以及排卵数量相似。结果表明，肾上腺分泌对于大鼠将血清LH和FSH排卵前激增的时间或排卵时间与14小时光照：10小时黑暗周期同步并非必需，且慢性肾上腺切除大鼠的LH和FSH排卵前激增未改变。
