Haemoglobin genotype, ABO blood groups and carcinoma of the cervix.

Genetic factors have been suggested as having a possible aetiological role in the incidence of carcinoma of the cervix. With the high frequency of carcinoma of the cervix in Ibadan as well as the high incidence of sickle-cell trait, the haemoglobin genotypes and ABO blood groups were analysed in patients managed for carcinoma of the cervix uteri in the University College Hospital, Ibadan. No significant association was found between any haemoglobin genotype or blood group and carcinoma of the cervix. The protection afforded against malaria by the haemoglobin S trait does not seem to protect against the development of invasive carcinoma of the cervix.