Kunstyr I, Ammerpohl E, Meyer B
Lab Anim Sci. 1977 Oct;27(5 Pt 2):782-8.
Experimental infection of the nude (nu/nu) mouse with the intestinal flagellate, Spironucleus (Hexamita) muris, was used as animal model for immunologic studies and for the testing of protozoa cides. The fecal discharge of cysts was shown to correlate with the immune status of the host. It was dependent on the strain, presence of the thymus (nu/nu and nu/+), and age (immunologic maturity). Four protozoacides (dimetridazole, metronidazole, tinidazole, and chlormethoxyacridylamino-diethylaminopropanol-dihydrochloride) were tested in infected mice. All lowered or suppressed the fecal discharge of cysts during treatment; however, the cysts reappeared in the feces when treatment, lasting 1-3 weeks, was terminated. It was concluded that experimental infection of the nude mouse with S muris was an excellent model for immunologic and pharmacologic studies.
将肠道鞭毛虫鼠螺旋体（六鞭原虫属）感染裸（nu/nu）鼠用作免疫研究和原生动物杀虫剂测试的动物模型。结果表明，囊肿的粪便排出量与宿主的免疫状态相关。它取决于菌株、胸腺的存在（nu/nu和nu/+）以及年龄（免疫成熟度）。在感染的小鼠中测试了四种原生动物杀虫剂（二甲硝唑、甲硝唑、替硝唑和氯甲氧基吖啶基氨基二乙氨基丙醇二盐酸盐）。在治疗期间，所有药物都降低或抑制了囊肿的粪便排出量；然而，当持续1 - 3周的治疗终止时，囊肿又重新出现在粪便中。得出的结论是，用鼠螺旋体对裸鼠进行实验性感染是免疫和药理学研究的极佳模型。
