Eisenbrandt D L, Russell R J
Scan Electron Microsc. 1979(3):23-7.
An epizootic disease characterized by failure to gain weight, lethargy, enteropathy, and death developed in weanlings from a production colony of NIH/Nmri CV mice. Light microscopic and scanning electron microscopic examination of the intestine revealed large numbers of protozoan parasites identified as Spironucleus (Hexamita) muris. The extensive, entangled mass of organisms in the intestinal lumen enveloped the villi and continued deep within the crypts of Lieberkühn. Inflammation and significant intestinal lesions were not observed. The scanning electron microscopic appearance of the small intestine in spironucleosis gives credence to a pathogenesis of malabsorption with subsequent, severe malnutrition and death in weanling mice.
在NIH/Nmri CV小鼠生产群体的断奶幼鼠中出现了一种以体重不增、嗜睡、肠病和死亡为特征的 epizootic 疾病。对肠道进行光镜和扫描电镜检查发现大量被鉴定为鼠螺旋体（六鞭毛虫属）的原生动物寄生虫。肠腔内大量相互缠绕的生物体包绕绒毛，并深入利伯kühn隐窝内部。未观察到炎症和明显的肠道病变。螺旋体病中小肠的扫描电镜表现支持断奶幼鼠吸收不良继而严重营养不良和死亡的发病机制。
