Flatt R E, Halvorsen J A, Kemp R L
Lab Anim Sci. 1978 Feb;28(1):62-5.
An acute fatal disease occurred in a mouse colony at the authors' institution. The disease caused 50% mortality among weanling mice, and was characterized clinically by depression, rough hair coat, and distention of the abdomen. The most prominent gross lesions were watery fluid and gas in the small intestine. Numerous organisms identified as Hexamita muris were seen in direct smears of the intestinal fluid. Microscopic and electron microscopic examination revealed the same organisms in the intestinal crypts, within the mucosal epithelium, and in the lamina propria. Treatment with dimetridazole controlled the clinical disease but did not eliminate the infection.
作者所在机构的一个小鼠群体中发生了一种急性致命疾病。该疾病导致断奶小鼠的死亡率达50%，临床特征为精神沉郁、被毛粗糙和腹部膨胀。最显著的大体病变是小肠内有水性液体和气体。在肠液的直接涂片上可见大量被鉴定为鼠六鞭毛虫的生物体。显微镜和电子显微镜检查显示，在肠隐窝、黏膜上皮内和固有层中存在相同的生物体。用二甲硝唑治疗可控制临床疾病，但不能消除感染。
