George W D
Langenbecks Arch Chir. 1977 Nov;345:111-3. doi: 10.1007/BF01305456.
The results of clinical trials for early cancer of the breast were assessed in terms of survival, morbidity, and the rate of local recurrance. Simple mastectomy appeared to be the operation of choice because survival following this procedure was equal to that following more radical operations, but the morbidity was less. Partial mastectomy was found to be an unsatisfactory method of treatment. Simple mastectomy should be combined with removal of the lower axillary nodes to allow accurate staging of the disease. Postoperative radiotherapy did not influence survival, but did increase morbidity. It may be best to restrict its use to the treatment of local recurrance. Improvement in survival figures may be seen by use of adjuvant chemotherapy, or by more widespread use of screening programmes.
根据生存率、发病率和局部复发率对早期乳腺癌的临床试验结果进行了评估。单纯乳房切除术似乎是首选手术，因为该手术后的生存率与更根治性手术的生存率相当，但发病率较低。发现部分乳房切除术是一种不理想的治疗方法。单纯乳房切除术应与腋下低位淋巴结清扫术相结合，以便准确进行疾病分期。术后放疗不影响生存率，但会增加发病率。最好将其使用限制在局部复发的治疗上。通过使用辅助化疗或更广泛地开展筛查项目，可能会提高生存率。
