Staessen J, Bulpitt C J, Roels H, Bernard A, Fagard R, Joossens J V, Lauwerys R, Lijnen P, Amery A
Br J Ind Med. 1984 May;41(2):241-8. doi: 10.1136/oem.41.2.241.
The 24 hour urinary excretion of cadmium (U-Cd) and lead (U-Pb), and the excretion of beta-2- microglobulins and retinol binding protein concentration in spot urines, were determined in a random 4% sample of the population of a small Belgian town. Blood pressure and body weight were measured on two separate occasions. U-Cd averaged 2.4 nmol/24 h in 46 youths, increased with age, and was significantly higher in 57 adult men as compared with 59 women (9.3 v 7.2 nmol/24 h; p less than 0.01). U-Pb averaged 28 nmol/24 h in youths and similarly increased with age: adult men excreted more lead than women (64 v 40.0 nmol/24 h; p less than 0.001). Among men, manual workers excreted more cadmium (12.6 v 7.5 nmol/24 h; p less than 0.05) but a similar amount of lead (62 v 61 nmol/24 h) compared with office workers. After adjusting for sex and age, U-Cd and U-Pb were not related to body weight and cigarette consumption. In simple regression analysis, U-Cd was positively correlated with both systolic (r = +0.30; p less than 0.05) and diastolic (r = +0.38; p less than 0.01) blood pressure in women. After adjusting for other contributing variables, however, a weak but negative relation became apparent between systolic pressure and U-Cd in women (t = -2.21; p = 0.033) and between diastolic pressure and U-Cd in men (t = -2.04; p = 0.047). In women urinary beta-2-microglobulin was related to diastolic pressure (r-0.44; p<0.01) and after adjusting for age to both systolic (t=2.75; p=0.009) and diastolic (t=-3.07; p=0.004) pressure. In none of the sex-age groups did U-Pb and retinol binding protein contribute to the blood pressure variability.
在比利时一个小镇随机抽取的4%的人口样本中，测定了24小时尿镉（U-Cd）和尿铅（U-Pb）排泄量，以及即时尿中β-2-微球蛋白排泄量和视黄醇结合蛋白浓度。在两个不同时间测量了血压和体重。46名年轻人的U-Cd平均为2.4 nmol/24小时，随年龄增加而升高，57名成年男性的U-Cd显著高于59名女性（9.3对7.2 nmol/24小时；p<0.01）。年轻人的U-Pb平均为28 nmol/24小时，同样随年龄增加而升高：成年男性排出的铅比女性多（64对40.0 nmol/24小时；p<0.001）。在男性中，体力劳动者排出的镉更多（12.6对7.5 nmol/24小时；p<0.05），但与办公室职员相比，排出的铅量相似（62对61 nmol/24小时）。在对性别和年龄进行校正后，U-Cd和U-Pb与体重和吸烟量无关。在简单回归分析中，女性的U-Cd与收缩压（r = +0.30；p<0.05）和舒张压（r = +0.38；p<0.01）均呈正相关。然而，在对其他影响变量进行校正后，女性收缩压与U-Cd之间出现了微弱但呈负相关的关系（t = -2.21；p = 0.033），男性舒张压与U-Cd之间也出现了类似关系（t = -2.04；p = 0.047）。在女性中，尿β-2-微球蛋白与舒张压有关（r = 0.44；p<0.01），在对年龄进行校正后，与收缩压（t = 2.75；p = 0.009）和舒张压（t = -3.07；p = 0.004）均有关。在任何性别-年龄组中，U-Pb和视黄醇结合蛋白均未对血压变异性产生影响。
