三氯乙烯中毒中的三氯乙醇
Trichloroethanol in trichloroethylene poisoning.
作者信息
Mikisková H, Mikiska A
出版信息
Br J Ind Med. 1966 Apr;23(2):116-25. doi: 10.1136/oem.23.2.116.
Abstract
Trichloroethylene and trichloroethanol were given intraperitoneally to guinea-pigs. Their effects were tested by measuring the threshold current intensity of electrical skin stimulation, the electrical excitability of the motor cerebral cortex, by recording and analysis of the electroencephalogram, and by electrocardiographic examination. The two compounds had similar effects on the nervous system and the heart, but trichloroethanol was the more effective by a factor of at least three. These results support the opinion of clinical investigators on the important role of trichloroethanol in the pathogenesis of trichloroethylene poisoning.
摘要
将三氯乙烯和三氯乙醇经腹腔注射给予豚鼠。通过测量皮肤电刺激的阈电流强度、运动性大脑皮层的电兴奋性、记录和分析脑电图以及进行心电图检查来测试它们的作用。这两种化合物对神经系统和心脏有相似的作用，但三氯乙醇的效力至少强三倍。这些结果支持了临床研究人员关于三氯乙醇在三氯乙烯中毒发病机制中重要作用的观点。
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