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DNA-binding peptides from rat liver and Novikoff hepatoma cells: quantitative level and possible biochemical differences.

作者信息

Gianfranceschi G L, Barra D, Coderoni S, Paparelli M, Venanzi F, Amici D

出版信息

Mol Biol Rep. 1983 Aug;9(3):169-74. doi: 10.1007/BF00775363.

DOI:10.1007/BF00775363
PMID:6685224
Abstract

DNA isolated from rat liver by intensive deproteinization with chloroform/isoamyl alcohol and phenol contains low molecular weight peptides in a quantity of about 20 micrograms/mg DNA. These peptides show high specific activity in inhibiting transcription in a reconstituted cell-free system with prokaryotic and eukaryotic RNA polymerase. Their level is markedly decreased in DNA prepared from Novikoff hepatoma cells. Moreover the amino acid analysis and the pattern of analytical separation by high performance liquid chromatography (HPLC) show some biochemical differences between DNA-binding peptides extracted from rat liver and Novikoff hepatoma cells. The possibility that carcinogenesis may involve mechanisms which lead to selective removal of some components of the DNA-binding peptides, is discussed.

摘要

相似文献

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本文引用的文献

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Mol Biol Rep. 1980 Jul 31;6(2):95-103. doi: 10.1007/BF00778436.
2
Inhibition of protein synthesis by low molecular weight factor(s) extracted from bovine seminal plasma.从牛精浆中提取的低分子量因子对蛋白质合成的抑制作用。
Cell Biol Int Rep. 1982 May;6(5):421. doi: 10.1016/0309-1651(82)90113-8.
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Mol Biol Rep. 1980 Dec 31;6(4):225-8. doi: 10.1007/BF00777529.
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On the role of small peptides in the regulation of RNA synthesis in Tetrahymena pyriformis.关于小肽在梨形四膜虫RNA合成调控中的作用
J Cell Sci. 1980 Oct;45:31-9. doi: 10.1242/jcs.45.1.31.
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Tumour promotor induces plasminogen activator.肿瘤促进剂诱导纤溶酶原激活剂。
Nature. 1976 Jan 22;259(5540):232-3. doi: 10.1038/259232a0.
6
Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.小牛胸腺中存在一种在体外控制DNA转录的肽因子的证据。
Biochim Biophys Acta. 1975 Nov 18;414(1):9-19. doi: 10.1016/0005-2787(75)90121-5.
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Restriction of template capacity of rat liver chromatin by a non-histone peptide from calf thymus.
Nature. 1976 Aug 12;262(5569):622-3. doi: 10.1038/262622a0.
8
Low molecular weight peptides controlling transcription are present in the calf thymus chromatin structure.
Mol Biol Rep. 1977 Dec;3(6):429-36. doi: 10.1007/BF00808384.
9
Control of transcription and translation by low molecular weight peptides (deprimerones) from chromatin and poly(A)-messenger RNA. Implication in the mechanism of carcinogenesis.
Biochim Biophys Acta. 1979 Sep 27;564(2):246-63. doi: 10.1016/0005-2787(79)90223-5.
10
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Proc Natl Acad Sci U S A. 1977 Mar;74(3):1152-6. doi: 10.1073/pnas.74.3.1152.